Comparative assessment of glycemic control in hypertensive patients treated with or without statins
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 2
Abstract
Background: It has been a matter of recent concern whether statins deteriorates diabetes mellitus or glycemic control. This association is worrying because diabetes doubles the risk of cardiovascular diseases and deaths, which accounts for about 50% of deaths in diabetes. Aims and Objectives: Comparison of the hemoglobin A1c (HbA1c) levels in hypertensive patients with or without atorvastatin was done to study the effects of atorvastatin at therapeutic doses on glycemic control. Statins association with blood glucose levels and their impacts in the management of patients are the focus of our study. Materials and Methods: A cross-sectional, prospective, hospital-based, observational study was conducted at Father Muller Medical College Hospital, 60 eligible patients included were randomized into 2 groups. Group A included 30 patients taking tablet atorvastatin 10mg once daily since 3 or more months. Group B, and Group B included 30 patients, not taking any statin therapy. Further in each group of 30 patients, 15 patients with hypertension only and remaining 15 patients with hypertension and diabetes both were included. Patients demographic profile, status of disease, treatment history, and HbA1c were recorded. Comparison of glycemic control was done using suitable statistical methods. Results: There was no statistically significant difference between two groups in terms of HbA1c levels. However, the patients on atorvastatin were found to have higher HbA1c levels compared to patients not on atorvastatin therapy. Conclusion: According to our study, atorvastatin had no significant impact on glycemic control; further larger trials are needed in this regard.
Authors and Affiliations
Praveen Kumar B, Scandashree K, Padmaja Udaykumar
Keywords
Related Articles
- EP ID EP288254
- DOI 10.5455/njppp.2017.7.0824719082016
- Views 66
- Downloads 0
Peripheral nerve conduction tests in patients with hypothyroidism and healthy volunteers: A comparative study
Background: The nervous system is the one of the most common sites get affected in patients with hypothyroidism and various tools have been developed for assessing it. Nerve conduction studies are one among them. Aims an...
Effects of chronic ingestion of Bisphenol A on gut contractility in rats
Background: Bisphenol A (BPA) is a plastic toxin widely used in manufacturing of plastic containers. It is known to produce a variety of toxic effects on body functions including reproduction, metabolism, and development...
Influence of athletic training on hematological parameters in runners: A cross-sectional study
Background: Athletics is one of the purest of all sports, relying solely on the strengths of the human body rather than technological implements to improve performances. Alterations of the red blood cell (RBC) sys...
Reflections: An approach to comprehensive learning in medical education
Reflection, an approach to learn from personal experience, inculcates the habit of taking responsibility for one’s actions and decisions. In medical education, reflection is evolving as an essential component to c...
Evaluation of antianxiety activity of ethanolic extract of leaves of Ocimum sanctum (tulsi) in albino mice
Background: Anxiety is a normal emotional behavior, however, becomes pathological precipitating cardiovascular and psychiatric disorders when it is severe. Many allopathic drugs are available to treat anxiety disorders,...