Comparative assessment of serum liver enzymes (AST and ALT) in thalassemia patients of Murshidabad and matched controls
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 11
Abstract
Patients with thalassemia syndrome, a group of inherited autosomal recessive haematologic disorder, need multiple blood transfusions, a complication of which is iron overload. Though life saving, but chronic blood transfusion can lead to lethal iron overload injury of liver, often characterized by the development of fibrosis and eventually, cirrhosis and increased serum ferritin. Liver enzymes are raised and indicative of liver injury in transfusion dependant thalassemia patients. To our knowledge no data are available on values of liver enzymes in patients with thalassemia in Murshidabad district. The study was carried out on 50 thalassemia cases and 50 age, sex matched controls to observe any alteration of serum AST and ALT and also whether the alteration could be correlated with common haematological indices. Compared to controls, the cases had significantly higher liver enzymes and there was positive correlation between high ferritin and high liver enzymes level. Taken together, high ferritin and liver enzymes levels might be important predictors for morbidity and mortality in thalassemia.
Authors and Affiliations
Dr. Angshuman De, Dr Debopriyo Samaddar, Dr. Arya Sen, Dr. Pradyot Kumar Sen
Keywords
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- EP ID EP415468
- DOI 10.9790/0853-1711050105.
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