COMPARATIVE EFFECT OF AQUEOUS AND ETHANOLIC EXTRACTS OF TETRAPLEURA TETRAPTERA (AIDAN) FRUIT ON SOME HAEMATOLOGICAL PARAMETERS OF FEMALE WISTAR RATS
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 5
Abstract
Extracts of Tetrapleura tetraptera have been employed in the management and treatment of various ailments. This study examined and compared the effects of aqueous and ethanolic extracts of Tetrapleura tetraptera fruit on some haematological parameters in female wistar rats. 15 female wistar rats (180-200g) fed with rat feed and water ad libitum were randomly assigned into three groups (n=5) thus: control, aqueous and ethanolic groups. The three groups were treated with daily oral administration of 0.2mL normal saline, aqueous (60mg/kg body weight) and ethanolic (40mg/kg body weight) extracts of Tetrapleura tetraptera respectively for 21 days. Blood samples were collected from each animal through cardiac puncture for haematological analysis. Red cell indices, platelets count and platelet large cell ratio were not significantly different among the three groups. Mean platelet volume and platelet distribution width were significantly decreased in aqueous (p<0.05) and ethanolic (p<0.01) groups compared with control. Total white blood cell and lymphocytes counts were significantly (p<0.05) increased in aqueous group compared with control. Neutrophils count was significantly (p<0.05) decreased in aqueous group compared with control. Total white blood cell count was significantly (p<0.01) decreased in ethanolic group compared with aqueous group. Both aqueous and ethanolic extracts of the fruit exhibited the same effect. Both had no significant effect on platelet count and red cell indices but decreased platelet distribution width and mean platelet volume. Moderate use of both extracts is advised as excess use may be detrimental to individuals with bleeding and/or blood coagulation disorders.
Authors and Affiliations
Augustine Lishilinimye Udefa
Keywords
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