Comparative Effect of Chamomile Mouthwash and Topical Mouth Rinse in Prevention of Chemotherapy-Induced Oral Mucositis in Iranian Pediatric Patients with Acute Lymphoblastic Leukemia
Journal Title: Iranian Journal of Blood and Cancer - Year 2017, Vol 9, Issue 3
Abstract
Background: Oral mucositis afflicts more than 3/4 of patients with cancer under chemotherapy. In acute cases it could lead to brain damage caused by hypoxia and even death due to airway obstruction and reduction of chemotherapy drug dose. We aimed to compare the effects of topical mouth rinse and chamomile mouthwash in prevention of oral mucositis caused by chemotherapy in children with cancer. Methods: The study was a randomized double-blind clinical trial on 62 children aged 6-15 years with acute lymphoblastic leukemia under chemotherapy. The participants were divided randomly into two groups. The first group used topical mouth rinse and the second group started to use chamomile mouthwash a day before chemotherapy through 14 days. Mucous membrane status was assessed before starting the treatment (one day before chemotherapy), 7th and 14th day and it was reviewed based on WHO oral mucositis check list assessment and then registered by the researcher. Results: The results showed that the frequency of severity of oral mucositis in both groups did not have any significant difference 7 days after chemotherapy (P=0.46). The severity of oral mucositis in those who had used chamomile mouthwash 14 days after chemotherapy was significantly lower than those who used topical mouth rinse (Z=3.23, P=0.001). Conclusion: In short term, using chamomile mouthwash and topical mouth rinse to prevent oral mucositis is effective in children with cancer. Iranian Registry of Clinical Trials: IRCT2015040821658N1.
Authors and Affiliations
Fatemeh Pourdeghatkar, Minoo Motaghi, Bahram Darbandi, Adel Baghersalimi
Keywords
Related Articles
- EP ID EP245874
- DOI -
- Views 162
- Downloads 1
Results of Transcranial Doppler in Children with Sickle Cell Disease: Correlation between the Time-Averaged Mean of Maximum Velocity and Some Hematological Characteristics
Abstract Background: Transcranial Doppler ultrasonography results have not been previously studied in among Iranian sickle cell anemia patients. The present study was performed to evaluate the pattern of intracranial flo...
Evaluation of Leukoreduction in Packed Cell Units Filtered by Home-Made Bedside Filters: Pre and Post Revision of Product Technology and Materials According to Standard Values
Introduction: Leukocytes causing a wide variety of side effects after transfusion are present in all blood products prepared by standard methods. As a consequence, the use of filter technology for leukoreduction has been...
Rhabdomyosarcoma of the Lower Eye Fornix and Conjunctiva in a Child
This article has no abstract.
Hemorrhage Treatment Report of Patients Suffering from Glanzmann’s Thrombasthenia Resulting Hospitalization from 2006 to 2011 at Mofid Children’s Hospital
Background: The present study evaluated treatment outcomes and the treatment indexes among Glanzmann’s patients in Mofid Children’s Hospital, Tehran, Iran. Patients and Methods: A retrospective cross-sectional study was...
Short-term Chelating Efficacy of Deferoxamine in Iron Overloaded Rat Hepatocytes
Abstract Background: Iron overload is a clinical consequence of repeated blood transfusions and causes significant organ damage, morbidity, and mortality in the absence of proper treatment. The primary targets of Iron ch...