Comparative effect of diclofenac sodium and dexamethasone on incisional wound healing in dogs
Journal Title: Scientific Journal of Veterinary Advances - Year 2012, Vol 1, Issue 4
Abstract
The study was carried out to compare and evaluate the effect of diclofenac sodium, a non-steroidal anti-inflammatory drug (NSAID) and dexamethasone, a steroidal, anti-inflammatory drug on incisional wound healing in dogs. Fifteen (15) clinically healthy, mixed sex, intact Nigerian local dogs free of dermatological lesion with mean age of 14.97±3.7 months (Mean ± SD) and mean body weight of 10.73± 2.6kg (Mean ± SD) were used for the study. The dogs were randomly divided into three treatment groups: A, B and C comprising of five dogs per group. A caudal mid-ventral laparotomy skin incision was made to create surgical wounds. Immediately after anesthetic recovery, 7.5% diclofenac sodium injection intramuscularly at standard clinical therapeutic dose rate of 2.5mg kg-1 was administered to group A for three day, 2.5% dexamethasone injection intramuscularly at standard clinical therapeutic dose rate of 0.25mg kg-1 was administered to the group B for three days. Group C were not treated with any anti-inflammatory medication. Subjectively, diclofenac sodium group shows shorter healing interval compare to dexamethasone group (P<0.05). Objective histological evaluation at day 7 and 14 revealed low inflammatory density in group B compared to A and C, fibroblast, collagen fibers, and surface keratinization was higher in group A at day 7 and 14 post surgery compared to B and C suggestive of faster healing in diclofenac sodium group compare to dexamethasone group. There was statistical significant different (P<0.05) among the groups. It is concluded that diclofenac sodium when used as an anti inflammatory agent post operative does not interfere with surgical wound healing.
Authors and Affiliations
A. A. Abubakar*| Department of Veterinary Surgery and Radiology, Usmanu Danfodiyo University, Sokoto., J. A. Maiye| Department of Veterinary Surgery and Radiology, Usmanu Danfodiyo University, Sokoto., A. S. Yakubu| Department of Veterinary Surgery and Radiology, Usmanu Danfodiyo University, Sokoto., B. Saidu| Department of Veterinary Physiology and Biochemistry, Usmanu Danfodiyo University, Sokoto., U. Adamu| Department of Theriogenology and Animal Production, Usmanu Danfodiyo University, Sokoto., S. M. Sahabi| Department of Histhopathology, Usmanu Danfodiyo University Teaching Hospital, Usmanu Danfodiyo University, Sokoto
Keywords
Related Articles
- EP ID EP869
- DOI -
- Views 675
- Downloads 33
The prevalence of malaria and typhoid co-infection in pregnant women attending antenatal in Wuse general hospital Abuja, Nigeria
Malaria and typhoid fever are both endemic in the tropics and pregnant women constitute one of the high risk groups. The objective is to determine the rate of malaria- typhoid co-infection in pregnant women attending ant...
Bovine foetal wastage and its economic implication: a six-year (2003 – 2008) retrospective study in an abattoir in northwestern, Nigeria
Pregnancy wastage has been reported to account for about 20-25% of the fall in livestock production in Sub-Saharan Africa. In the light this fact, a six-year (2003 – 2008) retrospective study based on abattoir records wa...
Host range and transmission of Tobacco streak virus (TSV) causing cotton mosaic disease
Tobacco streak virus (TSV) causing cotton mosaic disease was found to be transmissible by mechanical means specially when extracts were made in neutral phosphate buffer 0.02M containing reducing agent like 2-Mercaptoetha...
Influence of Cymbopogon proximus extract on lipid profile, biochemical hematological and coagulation parameters of hyperlipidemic albino rats
The objective of this work was to investigate the possible hypolipidemic activity and side effects of the C. proximus extract alone and combined with cholestyramine with half therapeutic doses by studying changes in dif...
Prevalence of yersinia enterocolitica and yersinia pseudotuberculosis in pigs in Zuru local government area, Kebbi state
The study was carriedout to establish the prevalence of Yersinia enterocolitica and Yersiniapseudotuberculosis in pigs in Zuru Local Government of Kebbi State. Feacalsamples were collected from the randomly selected pigs...