Comparative effect of diclofenac sodium and dexamethasone on incisional wound healing in dogs
Journal Title: Scientific Journal of Veterinary Advances - Year 2012, Vol 1, Issue 4
Abstract
The study was carried out to compare and evaluate the effect of diclofenac sodium, a non-steroidal anti-inflammatory drug (NSAID) and dexamethasone, a steroidal, anti-inflammatory drug on incisional wound healing in dogs. Fifteen (15) clinically healthy, mixed sex, intact Nigerian local dogs free of dermatological lesion with mean age of 14.97±3.7 months (Mean ± SD) and mean body weight of 10.73± 2.6kg (Mean ± SD) were used for the study. The dogs were randomly divided into three treatment groups: A, B and C comprising of five dogs per group. A caudal mid-ventral laparotomy skin incision was made to create surgical wounds. Immediately after anesthetic recovery, 7.5% diclofenac sodium injection intramuscularly at standard clinical therapeutic dose rate of 2.5mg kg-1 was administered to group A for three day, 2.5% dexamethasone injection intramuscularly at standard clinical therapeutic dose rate of 0.25mg kg-1 was administered to the group B for three days. Group C were not treated with any anti-inflammatory medication. Subjectively, diclofenac sodium group shows shorter healing interval compare to dexamethasone group (P<0.05). Objective histological evaluation at day 7 and 14 revealed low inflammatory density in group B compared to A and C, fibroblast, collagen fibers, and surface keratinization was higher in group A at day 7 and 14 post surgery compared to B and C suggestive of faster healing in diclofenac sodium group compare to dexamethasone group. There was statistical significant different (P<0.05) among the groups. It is concluded that diclofenac sodium when used as an anti inflammatory agent post operative does not interfere with surgical wound healing.
Authors and Affiliations
A. A. Abubakar*| Department of Veterinary Surgery and Radiology, Usmanu Danfodiyo University, Sokoto., J. A. Maiye| Department of Veterinary Surgery and Radiology, Usmanu Danfodiyo University, Sokoto., A. S. Yakubu| Department of Veterinary Surgery and Radiology, Usmanu Danfodiyo University, Sokoto., B. Saidu| Department of Veterinary Physiology and Biochemistry, Usmanu Danfodiyo University, Sokoto., U. Adamu| Department of Theriogenology and Animal Production, Usmanu Danfodiyo University, Sokoto., S. M. Sahabi| Department of Histhopathology, Usmanu Danfodiyo University Teaching Hospital, Usmanu Danfodiyo University, Sokoto
Keywords
Related Articles
- EP ID EP869
- DOI -
- Views 710
- Downloads 33
Evaluation of antitrypanosomal activity of Adansonia digitata (methanol seed extract) in Albino mice
Adansonia digitata, a shrub used in traditional medicine for the treatment of cancer was investigated for the treatment of experimental trypanosomiasis. Methanol seed extracts of the seed of Adansonia digitata was invest...
Cattle keepers’ perception on the most important infectious diseases that limit milk production in Benin and municipalities at higher risks
In Benin herders are confronted with a number of infectious diseases whose epidemiology remains unclear. The objective of the present study was to assess cattle keepers’ perception on municipalities of Benin at higher ri...
Prevalence of lead (pb) residues in kidney and liver of slaughtered pigs at Sabo-Wakama market of Akun development area of Nasarawa state, Nigeria
The prevalence of Lead (Pb) in liver and kidney samples of slaughtered pigs at Sabo Wakama Market of Akun-Development Area of Nasarawa State was determined using Atomic Absorption Spectrophotometer. A total of thirty num...
The effect of intramuscular injection of spiramycin at therapeutic dose on some blood biochemical and hematological parameters in Assaf sheep
Spiramycin is used to treatment of different bacterial and protozoal infection in different animal species including sheep, to the authors’ knowledge there are no studies about effects of spiramycin in sheep blood bioche...
Effect of use cumulative levels of sesame (sesamum indicum-l) meal with phytase enzyme on performance of broiler chicks
For investigate theeffect of feeding the levels of Sesame meal (SSM) for Soybean meal (SBM) withthe phytase enzyme (Phy) on performance of broiler chickens, total 384 one daysold broilers chickens (Ross 308) at completel...