COMPARATIVE EFFECT OF VITAMINS A AND E ON SPERM MORPHOLOGY OF NICOTINE-TREATED WISTAR RATS
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 1
Abstract
This study compared the effect of vitamins A and E on sperm morphology of nicotine-treated rats. Thirty male wistar rats were randomly assigned into six groups (n=5) thus: control received 0.2mL/kg of normal saline; Nicotine (N) group received 1mg/kg of nicotine; Vit A group received 1μg/kg of vitamin A; Vit E group received 50mg/kg of vitamin E; N+Vit A group received both nicotine and vitamin A and N+Vit E group received both nicotine and vitamin E. All groups had access to rat feed and water throughout the study period (3 weeks treatment period and 1 week acclimatization period). Semen were collected for evaluation of sperm morphology. Total sperm defect was significantly increased (p<0.05) in Nicotine group compared with control and decreased (p<0.05) in Vit A, Vit E, N+Vit A and N+Vit E groups compared with Nicotine group. Sperm head defect was significantly (p<0.05) decreased in Vit E and N+Vit E groups compared with Nicotine group. Sperm tail defect was significantly increased (p<0.05) in Nicotine and N+Vit A groups compared with control and decreased (p<0.05) in Vit A and Vit E groups compared with Nicotine group. Normal sperm morphology was significantly decreased (p<0.05) in Nicotine group compared with control and increased (p<0.05) in other treatment groups compared with Nicotine group. Nicotine thus exhibited deleterious effect on sperm morphology but both vitamins A and E were effective in protecting sperm cells from nicotine-induced damage. Vitamin E exhibited a slightly greater protective effect than vitamin A.
Authors and Affiliations
Augustine Lishilinimye Udefa
Keywords
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- EP ID EP618618
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