COMPARATIVE EFFECT OF VITAMINS A AND E ON SPERM MORPHOLOGY OF NICOTINE-TREATED WISTAR RATS
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 1
Abstract
This study compared the effect of vitamins A and E on sperm morphology of nicotine-treated rats. Thirty male wistar rats were randomly assigned into six groups (n=5) thus: control received 0.2mL/kg of normal saline; Nicotine (N) group received 1mg/kg of nicotine; Vit A group received 1μg/kg of vitamin A; Vit E group received 50mg/kg of vitamin E; N+Vit A group received both nicotine and vitamin A and N+Vit E group received both nicotine and vitamin E. All groups had access to rat feed and water throughout the study period (3 weeks treatment period and 1 week acclimatization period). Semen were collected for evaluation of sperm morphology. Total sperm defect was significantly increased (p<0.05) in Nicotine group compared with control and decreased (p<0.05) in Vit A, Vit E, N+Vit A and N+Vit E groups compared with Nicotine group. Sperm head defect was significantly (p<0.05) decreased in Vit E and N+Vit E groups compared with Nicotine group. Sperm tail defect was significantly increased (p<0.05) in Nicotine and N+Vit A groups compared with control and decreased (p<0.05) in Vit A and Vit E groups compared with Nicotine group. Normal sperm morphology was significantly decreased (p<0.05) in Nicotine group compared with control and increased (p<0.05) in other treatment groups compared with Nicotine group. Nicotine thus exhibited deleterious effect on sperm morphology but both vitamins A and E were effective in protecting sperm cells from nicotine-induced damage. Vitamin E exhibited a slightly greater protective effect than vitamin A.
Authors and Affiliations
Augustine Lishilinimye Udefa
Keywords
Related Articles
- EP ID EP618618
- DOI -
- Views 141
- Downloads 0
EVALUATION OF HEPATOPROTECTIVE EFFECTS OF Setaria megaphylla (STEUD) T. DUR AND SPHINZ (POACEAE) ROOT EXTRACT ON PARACETAMOL-INDUCED INJURY IN RATS.
Background: Setaria megaphylla (Steud) T. Dur and Schinz (Poaceae), is a popular medicinal plant used by the indigenes of Niger Delta Nigeria to treat malaria, hemorrhoids, urethritis, inflammation, diabetes, fevers and...
INTRAUTERINE INSEMINATION (IUI) PREGNANCY RATE AFTER HYSTEROSALPINGOGRAPHY (HSG)
Objective: To see the pregnancy rate through IUI after doing HSG. Methods: 40 women with unexplained infertility stimulated for ovulation induction then 20 of them was undergo IUI (GP A) and the other 20 we do for them H...
OUTCOME OF CLOSE LATERAL INTERNAL ANAL SPHINCTEROTOMY FOR CHRONIC ANAL FISSURE UNDER LOCAL ANESTHESIA
Introduction: Anal fissure is a linear tear in the lower anoderm that presents with moderate to severe pain during and after defecation along with streaks of fresh blood. The pathophysiology is thought to be related to t...
PREVALENCE OF POLYCYSTIC OVARIAN SYNDROME WITH ASSOCIATED RISK FACTORS AND IMPACT ON WELL-BEING AMONG WOMEN IN REPRODUCTIVE AGED (18-45) YEARS IN AL - MADINAH 2017
Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women worldwide. There a shortage of recent data about its prevalence and epidemiologic features in Saudi Arabia. Objectives: The study aimed...
UPDATE OF THE NEUROPROTECTIVE EFFECT OF MAO-B INHIBITORS THERAPY ON PARKINSON’S DISEASE
Parkinson’s disease was marked by stiffness, bradykinesia, resting tremor, and postural instability occurring due to various causes that were mainly idiopathic causes. Monoamine oxidase B inhibitor, also known as MAO-B i...