Comparative Efficacy of Amantadine Hydrochloride versus Amantadine Sulphate in Treating Egyptian Patients with Chronic HCV
Journal Title: International Journal of TROPICAL DISEASE & Health - Year 2014, Vol 4, Issue 10
Abstract
Background: Pegylated interferon (peg-IFN) alpha in combination with weight-based doses of ribavirin is currently recommended as a standard-of-care treatment for chronic hepatitis C virus (HCV) infection. However, the low response rate with interferon as well as the high occurrence of side effects has prompted investigators to search for other drugs which may be efficacious in the treatment of hepatitis C. Objectives: To evaluate the efficacy of amantadine hydrochloride versus amantadine sulphate monotherapy when administered to naïve Egyptian patients with chronic hepatitis C. Patients and Methods: Fifty Egyptian patients with chronic HCV were randomized to receive amantadine hydrochloride (100mg) two times daily or amantadine sulphate (100mg) two times daily for sixty days. Results: Patients treated with amantadine hydrochloride and amantadine sulphate showed highly significant reduction in serum AST and ALT levels but there was non significant reduction in HCV RNA viral load. Patients tolerate therapy well with no drop out. Conclusion: Amantadine oral therapy appears to have activity for treating hepatitis C.
Authors and Affiliations
Hosny Salama, Abd El Rahman Zekri, Heba Farouk Salem, Dalia Omran, Mohamad Abd El Rahman
Keywords
Related Articles
- EP ID EP343502
- DOI 10.9734/IJTDH/2014/11789
- Views 57
- Downloads 0
Comparative Efficacy of Amantadine Hydrochloride versus Amantadine Sulphate in Treating Egyptian Patients with Chronic HCV
Background: Pegylated interferon (peg-IFN) alpha in combination with weight-based doses of ribavirin is currently recommended as a standard-of-care treatment for chronic hepatitis C virus (HCV) infection. However, the lo...
Effect of Helicobacter pylori Infection on Selected Biochemical Parameters of Hypertensive Patients at Dschang District Hospital in Cameroon
Aims: Helicobacter pylori infection is an important cause of peptic ulcer disease and other gastrointestinal disorders. The gastritis caused by H. pylori leads to lipid metabolism disorders that may act as risk factors f...
Efficacy of Fluorescence Microscopy in the Diagnosis of Tuberculosis in Guyana
Background: Tuberculosis is one of the potentially serious human diseases and is still one of the major causes of mortality. It ranks as the second most leading cause of death from a single infectious agent, after the hu...
Cutaneous Leishmaniasis in Zliten, a New Focus in North West of Libya
Aims: This study was done to evaluate the epidemiological aspects of cutaneous leishmaniasis (CL) in the patients who were presented to dermatology clinic of main referral hospital in Zliten, and to discover its distribu...
Perception of Tetanus Toxoid Immunization among Women in a Niger Delta Community, Nigeria
Aims: To assess the awareness and knowledge of tetanus toxoid (TT) immunization among women in Alakahia, a community in Obio/Akpor LGA, Rivers State in the Niger Delta region of Nigeria. Study Design: This was a cross-se...