Comparative Evaluation Of Anticancer Potential Of Moringaoleifera , Ganodermalucidumand Silver Nanoparticles Against B reast And Liver Cancer Cell Lines And Related Pro And Anti Apoptotic Genes Profile
Journal Title: International Journal of Scientific Research and Management - Year 2017, Vol 5, Issue 3
Abstract
The present work aimed to evaluate the anticancer potentials concerning the cytotoxicity and anti - proliferative activity of L - amino acid Oxidase (LAAO) ,MoringaOleifera(MO) Methanol (MLM) and water extracts (MLW), Ganodermalucidum(GL), extracts as a natural products and Silver nanoparticles (AgNP) as well. Cytotoxic effect of test extracts on both breast (MCF - 7) an d liver(HEPG - 2) cancer cell lines varied according to test materials and could be arranged in the order of LAAO > MLM>AgNP> GL>MLW. Also, (MCF7) cell line was more sensitive to test materials compared with (HEPG2) cell line. Regarding the genotoxicity it was found that Bcl2 and survivineand caspase - 3 as antiapoptotic genes were significantly down regulated and P53 as proapoptotic genes was significantly up regulated in both cell lines
Authors and Affiliations
Aliaa Hussein
Keywords
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