COMPARATIVE EVALUATION OF ANTIDIABETIC AND ANTIOXIDANT POTENCY OF DIFFERENT EXTRACTS OBTAINED FROM MEMECYLON SPECIES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2017, Vol 9, Issue 2
Abstract
Objective: Memecylon species is being extensively used in traditional medicine for the treatment of skin disorders and it is proved to possess antidiabetic and anti-inflammatory properties. The present investigation was to study the effect of different solvent extracts of five Memecylon species such as M. umbellatum, M. talbotianum, M. edule, M. malabaricum and M. wightii on antidiabetic and antioxidant effects.Methods: Plant extracts were prepared using soxhlet apparatus using different solvents such as hexane, ethyl acetate, methanol and water and obtained extracts were subjected to antidiabetic (α-amylase and α-glucosidase inhibition assays) and antioxidant (2, 2-Diphenyl-2-Picryl Hydrazyl hydrate (DPPH), 2,2-Azino-bis (3-ethyl benzothiazoline-6-Sulfonic acid)diammonium salt (ABTS), Superoxide radical scavenging assay (SRSA) and reducing power assays) evaluated at different doses.Results: Methanol extracts of all five Memecylon species exhibited effective antidiabetic and antioxidant properties among them methanol extracts of M. malabaricum and M. talbotianum have highest biological activity. For α-amylase IC50 value for both M. malabaricum and M. talbotianum was found to be 100 and 130 µg/reaction and IC50 value for α-glucosidase was found to be 6.1 and 7.8 µg/reaction respectively. For DPPH the IC50value was found to be 190 µg/reaction, for ABTS 31-39 µg/reaction, for SRSA 950-1200 µg/reaction and for reducing power assay 420-490 µg/reaction respectively.Conclusion: The results indicate that methanol extracts of M. malabaricum and M. talbotianum possess potent in vitro antidiabetic and antioxidant activities compared to other Memecylon species.
Authors and Affiliations
Tumkur Ramasetty Bharathi, Harishchandra Sripathy Prakash
Keywords
Related Articles
- EP ID EP575839
- DOI 10.22159/ijpps.2017v9i2.15695
- Views 86
- Downloads 0
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD OF NEPAFENAC AND ITS DEGRADATION PRODUCTS: APPLICATION TO DEGRADATION KINETIC
Objective: The objective of present work was to develop and validate simple, precise, accurate and specific stability indicating method for determination of nepafenac in presence of its degradation products and applicati...
SYNTHESIS, REACTIVITY AND BIOLOGICAL EVALUATION OF TRIAZOLE: RECENT DEVELOPMENTS
This review summarizes the synthetic methods, reactions and biological applications of pharmacological important 1, 2, 4-triazole isomer and recent developments in their derivatives such as Mannich base, Schiff’s base,...
AMELIORATIVE ROLE OF BEE HONEY AND ROYAL JELLY AGAINST CISPLATIN INDUCED ALTERATION IN HEMATOLOGICAL PARAMETERS IN MALE WISTER ALBINO RAT
Objective: This study aims to investigate the ameliorative role of dietary bee honey and royal jelly against cisplatin-induced alterations in hematological parameters in male wistar albino rat.Methods: Male wistar albino...
IN VITRO ANTHELMINTIC EFFECTS OF SENNA OCCIDENTALIS (L.) LINK (LEGUMINOSAE) ON RAT TAPEWORM HYMENOLEPIS DIMINUTA
Objective: This study was conducted to evaluate the anthelmintic activity of ethanolic leaf extract of Senna occidentalis on rat tapeworm Hymenolepis diminuta.Methods: Adult H. diminuta worms were obtained from laborator...
CHROMATOGRAPHIC ISOLATION OF ALLIUM CEPA (SSP. RED ONION) AND ITS CYTOTOXIC ACTIVITY AGAINST HUMAN LIVER CARCINOMA CELL LINES (HEPG2)
Objective: The present study aimed to find out cytotoxic agent from Allium cepa L. (ssp. red onion) family Alliaceae as well as chromatographic isolation of its active constituents.Methods: The defatted methanol extract...