Comparative evaluation of blood culture, estimation of immunoglobulin m (igm) and c-reactive protein (crp) detection in the diagnosis of neonatal sepsis
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2014, Vol 6, Issue 2
Abstract
This clinical study was conducted to evaluate the diagnostic value of C-reactive protein (CRP), Immunoglobulin M (IgM) in the early diagnosis of neonatal sepsis. The diagnostic values of each marker separately or in combination were evaluated. Blood culture, IgM and CRP estimation were performed on 50 clinically suspected to have septicemia. Blood culture positive were seen in 54.0% cases with predominant organism being Klebsiella pneumoniae (47.8%) and among Gram positive Staphylococcus aureus (13.1%). IgM level >20mg/dl (cut off value) was found in 46.0%cases and CRP level >5mg/dl (cut off value) was seen in 52.0% of culture proven sepsis. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of CRP versus blood culture were 91.30, 81.40, 80.77 and 91.67 respectively, IgM versus blood culture were 86.90, 88.89, 86.96 and 88.89 respectively and combined IgM & CRP versus blood culture were 95.65, 81.48, 81.41 and 96.65 respectively. CRP is a single useful marker with high sensitivity and IgM with high specificity in predicting neonatal sepsis. Combination of these tests showed higher sensitivity and negative predictive value when compared to CRP and IgM estimation alone in diagnosing septicemia. CRP and IgM in combination sensitivity increased from 91.30%-95.65% and can be used as better predictor of neonatal infection and helpful in predicting neonatal sepsis while awaiting for culture report. We speculate a significant role of this combination in making decisions regarding antibiotics treatment and upgrading the level of medical care.
Authors and Affiliations
Kamble Arati Nagarathnamma T. ,, Asha Benakappa
Keywords
Related Articles
- EP ID EP406022
- DOI -
- Views 133
- Downloads 0
Plasma cells in health and disease
Plasma cells are the only cells that sustain antibody production and hence are an essential part of immune system. In the bone marrow plasma cells produce immunoglobulins which assure long-term humoral immune protection...
Psychomotor performance in indian antarctic expedition
The purpose of the study was to determine the impact of austere winter on psychomotor performance of expedition members who stayed for prolonged duration in Antarctica. Twenty-four volunteers (scientific and technical su...
Knowledge, attitude and practices of 2nd year mbbs students on over the counter drugs
Background: Practice of using OTC drugs is very common among medical students. Since OTC drugs are more easily accessible to them, in this study we intend to analyze knowledge, attitude and practices of second year MBBS...
A review on diagnostic dental radiation risk during pregnancy: justifying the dilemma-review
Pregnancy is accompanied by a variety of physiologic, anatomic and hormonal changes that can affect the oral health. However, these patients are not medically compromised and should not be denied dental treatment simply...
FEATURES OF ASSESSING CARCINOGENIC RISKS WHEN EXPOSED TO POPS IN AKTOBE OBLAST (THE REPUBLIC OF KAZAKHSTAN)
Pollution of POPs, which are carcinogens, has an adverse effect on the environment and human health. One of the crisis regions of Kazakhstan is considered the Aral Sea area. Shalkar and Irgiz villages are located in the...