COMPARATIVE EVALUATION OF BOLUS ADMINISTRATION OF ESMOLOL VERSUS LIGNOCAINE FOR PRESSOR RESPONSE ATTENUATION DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 72
Abstract
BACKGROUND Endotracheal intubation and anaesthesia have become an integral part of the anaesthesiologist’s contribution to the patient care. Endotracheal intubation is the translaryngeal placement of endotracheal tube into the trachea. General anaesthesia procedures involve many stressful events at various stages. There are certainly more stressful situations for the patient under general anaesthesia in regard to induction, intubation and extubation. Aims and Objectives- A comparative clinical evaluation of intravenous 2% Lignocaine and Esmolol in attenuating the cardiovascular changes to laryngotracheal stimulation in healthy normotensive patients during a widely used method of induction of anaesthesia in order to reduce the life-threatening complications in susceptible patients. MATERIALS AND METHODS A randomised controlled study was conducted at Osmania General Hospital. The sample size per group is 26. So, the minimum sample size required for the study is 54. In this study, a total of 60 subjects were included. Randomisation was done using simple randomisation technique. Statistical Analysis- Data analysis was done with the help of computer using Epidemiological Information Package (Epi Info ver 3.5.1). Statistical test, independent sample ‘t’ test was used after ascertaining normality to test the hypothesis. A probability value (p) of < 0.05 was to be considered as statistically significant. RESULTS There is high statistically significant difference in mean heart rate across the 2 groups (p < 0.001). The mean heart rate, blood pressure and mean arterial pressure of the esmolol group are the least. At 2 minutes following intubation, there is statistically significant difference in mean heart rate, mean systolic and diastolic pressure of patients across 2 groups (p < 0.001). The blood pressure and mean arterial pressure are lowest in the esmolol group than lignocaine. At 4 minutes following intubation, they are statistically significant. Patients in esmolol group are having significantly lower values than the lignocaine group. There is statistically significant difference in mean heart rate, blood pressure and mean arterial pressure of patients across 2 groups. CONCLUSION In this study, Esmolol has achieved a better attenuated rise in blood pressure when compared to lignocaine.
Authors and Affiliations
Sambasiva Rao Jupalli, Sridhar I, Kiran Madhala
Keywords
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- EP ID EP265607
- DOI 10.14260/Jemds/2017/1121
- Views 78
- Downloads 0
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