COMPARATIVE EVALUATION OF EFFECT OF ORAL CLONIDINE AND ORAL GABAPENTIN PREMEDICATION ON INTRAOPERATIVE HAEMODYNAMIC CHANGES IN LAPAROSCOPIC CHOLECYSTECTOMY- A PROSPECTIVE, RANDOMIZED, DOUBLE- BLIND, PLACEBOCONTROLLED STUDY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 9
Abstract
BACKGROUND Laparoscopic surgeries form an essence of today's surgical practice. It has been adapted as standard procedure for cholecystectomy at most centres. Haemodynamic perturbations associated with pneumoperitoneum during laparoscopic cholecystectomy may cause serious health hazard to the patient. The aim of the study is to compare the effect of oral clonidine and gabapentin premedication on intraoperative haemodynamic stability with a placebo. MATERIALS AND METHODS A prospective, randomized, double-blind, placebo-controlled study was conducted on 90 patients with ASA physical status I and II aged between 20-60 years undergoing elective laparoscopic cholecystectomy. They were randomly allocated to one of the three groups containing 30 patients each. Group C (n=30) received 150? g clonidine, group G (n=30) received 600 mg gabapentin and group P (n=30) received a multivitamin tablet 2 hrs. prior to the surgical procedure. We then assessed haemodynamics of the patients with parameters HR, SBP, DBP, MAP at different points of time and any postoperative adverse events. RESULTS Demographically all the three groups were statistically comparable. Following data interpretation, it was observed that both clonidine and gabapentin group had significantly lower HR and BP changes than placebo group (P<0.05) during pneumoperitoneum. The incidence of adverse events was also comparable and not significant between the groups. CONCLUSION Clonidine 150 mcg and gabapentin 600 mg are better in maintaining haemodynamic stability than placebo during pneumoperitoneum with minor adverse events which were easily controllable.
Authors and Affiliations
Ravi Prakash, Rajesh Tope, Chitra Chatterji, Ashish Malik
Keywords
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- EP ID EP474159
- DOI 10.18410/jebmh/2018/158
- Views 64
- Downloads 0
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