Comparative Evaluation of Hyperbaric 0.5% Bupivacaine-Clonidine and only 0.5% Bupivacaine for Spinal Anaesthesia
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2017, Vol 4, Issue 2
Abstract
Pain of any kind is distressing to the life style of human being and relief of pain becomes mandatory all the time. Intraoperative as well as postoperative pain is of concern as it results in morbidity and mortality. Postoperative pain relief is beneficial in al aspects and hence efforts have been going on to introduce new techniques or newer drugs to relieve pain. Intrathecal use of adjuvant with conventional local anaesthetic agents has proved to be beneficial in this regard. Clonidine is an imidazoline derivative with 2 adrenergic agonist activity has analgesic effect at spinal level mediated by postsynoptically situated 2 adrenoreceptors in dorsal horn of spinal cord. It has intrinsic analgesic effect to control postoperative pain with potentiating quality of subarachnoid block. 100 patients of either sex were divided into 2 equal groups. In group A 0.5% Bupivacaine 3cc with normal saline was administered and in group B 0.5% Bupivacaine 3 cc with 30 µgm of Clonidine with normal saline was administered intrathecally. It was observed that, in Clonidine group, the onset of sensory block, highest dermatome level, onset of motor block, duration of sensory block, duration of motor block, time for 2 segment regression of sensory block, total duration of surgical anaesthesia, quality of sensory and motor block sedation score, requirement of analgesic supplementation was superior in Clonidine group as compare to control group. The haemodynamic parameters as mean changes in pulse rate and systolic blood pressure and incidence of intraoperative and postoperative complications was negligible in both groups. Thus it was concluded that, intrathecal Clonidine is efficient adjuvant along with 0.5% Bupivacaine intrathecally as it improves the quality of sensory block and provides satisfactory prolonged postoperative analgesia with haemodynamic stability and minimum side effects. It is recommended to use Clonidine along with local anaesthetic intrathecally for lower abdominal surgeries requiring postoperative pain relief.
Authors and Affiliations
Rahul Kore
Keywords
Related Articles
- EP ID EP464971
- DOI 10.21088/ijaa.2349.8471.4217.18
- Views 90
- Downloads 0
Hemodynamic Effects of Dexmedetomidine in Patients undergoing Off Pump Coronary Artery Bypass Grafting Surgery (OPCAB): A Placebo Controlled Prospective Randomized Double Blind Study
Aims & Objectives: To study the effect of Dexmedetomidine on hemodynamic parameters in cases of OPCAB during • Intubation, • Intraoperatively during grafting and • Postoperatively till extubation. Methods: A prospecti...
Platelet Indices as Indicators of Severity of Sepsis
o compare Platelet indices with SOFA scores of patients with sepsis in order to assess the relationship between platelet indices like MPV and PDW and the severity of sepsis. Settings and Design: A total of 100 patients w...
A Comparative Study of Intrathecal Dexmedetomidine and Buprenorphine as Adjuvants to Hyperbaric Bupivacaine for Infraumbilical Surgeries
Background: Various adjuvants have been used with local anaesthetics in spinal anaesthesia to prolong the postoperative analgesia.Dexmedetomidine, alpha2-agonist is now being used as a neuraxial adjuvant The aim of the p...
Comparison of Sublingual Melatonin, Alprazolam and Melatonin - Alprazolam Combination on Anxiolysis and Sedation in Cataract Surgery: A Double Blinded Randomised Controlled Trial
Background: Preoperative anxiety is described as a state of uneasiness that mostpatients awaiting elective surgery experience and is a challenging concept in the preoperative care of the patients. Benzodiazepines are the...
A Case Report of Ca. Breast Patient with Metastasis, DVT and Hypoalbuminemia Posted for Modified Radical Mastectomy Under Thoracic Epidural Anaesthesia: A Challenge for Anaesthesiologist
Modified Radical Mastectomy, the surgical procedure for carcinoma of breast is routinely performed under general anaesthesia. Patient with lung metastasis and low serum albumin are at increased risk of perioperative morb...