Comparative Evaluation of Lymphocytic Count in Pre-menopausal Women with Iron Deficiency Anemia
Journal Title: Harsukh Educational Charitable Society International Journal of Community Health and Medical Research - Year 2017, Vol 3, Issue 4
Abstract
Background: The relationship between iron deficiency and infection susceptibility has been investigated. There is some evidence that iron is a fundamental element for normal development of the immune system and some clinical studies have emphasised the importance of iron in the integrity of the immune system. The effects of iron deficiency on cellular immune function remain controversial. Aim:To evaluate lymphocytic count in pre- menopausal women with Iron deficiency anemia.Materials and method: The study was conducted in the Department of General pathology of the medical institution. In the study group we included a total of 35 non- pregnant, pre-menopausal women between the ages of 18–40 years old presenting with IDA as the solitary pathology were included in the patient group. A total of 35 normal healthy women were also included in the study as control group. For the laboratory evaluation of blood parameters, we collected 5 mL of venous blood of subjects in sterile tube containing K3–EDTA anticoagulant. Peripheral blood smears (PBS) were prepared with Geimsa staining.Results: In the present study, the mean age of the patients in study group was 29.8 ± 8.32 years and in control group was 31.25+ 7.88 years.The mean CD3+, CD3+/CD4+, CD3+/CD8+, and CD19+ lymphocyte counts were 1.42, 0.81, 46, and 0.31 x 109/L, respectively, in study group, and 1.93, 0.52, 0.67, and 0.27 x 109/L, respectively, for the control group. The absolute T lymphocytes (CD3+) and subpopulations (CD4+, CD8+) in the iron-deficient group were significantly lower than in the control group. Conclusion: There are significant changes in the total lymphocyte counts in women with IDA. Due to decreased lymphocyte count in pre-menopausal women with IDA, these patients may be more prone to infection.
Authors and Affiliations
Parbhakar Kumar Chaudhary
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