Comparative Evaluation of Procalcitonin and Interleukin-6 as Diagnostic and Prognostic Biomarkers for Sepsis
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 10
Abstract
ABSTRACT Introduction: Diagnosis of sepsis is based on host’s systemic inflammatory response to infection including life-threatening organ dysfunction. Various biomarkers are available for diagnosis and prognostication of patients with sepsis, Procalcitonin (PCT) and interleukin-6 (IL-6) being most reliable. Aim: To compare PCT and IL-6 as diagnostic and prognostic biomarkers of sepsis in patients admitted with Systemic Inflammatory Response Syndrome (SIRS). Materials and Methods: After taking Ethical Committee Approval, a total of 51 patients aged 15-65 years admitted in ICU with SIRS were identified. Patients with baseline Sequential Organ Failure Assessment (SOFA) score of 0 and 1 were categorised into non-infectious group and SOFA of greater than 2 into infectious group. Procalcitonin and IL-6 were measured on day 1 and 3 using enzyme-linked immunosorbent assay. Collected data were analysed using SPSS software version 22.0. Parametric data were compared using Student’s t-test. Other tests used were Mann-Whitney U test, Pearson’s chi-square test, Fisher’s-exact test, Friedman’s test, ANOVA. Results: PCT (day 1 and 3) was significantly higher in the infectious group than non-infectious group (p<0.001) and day 1 PCT was found to be better in diagnosing sepsis with Area Under the Curve (AUC) of 0.90 (95% CI, 0.789-1.000) (p=0.001). Unlike day 1 PCT, day 3 PCT was statistically significant in predicting mortality with AUC of 0.982 (95% CI, 0.956-1.000) (p<0.005). IL-6 was found to be better in predicting mortality with day 1 AUC of 0.987 (95% CI, 0.966-1.000) (p<0.005) and day 3 AUC of 0.981 (95%CI, 0.953-1.000) (p<0.005). Multivariate analysis of mortality prediction showed day 1 IL-6 to have a better mortality prediction value (p=0.047). Conclusion: PCT on day 1 was found to be better in identifying sepsis and day 1 IL-6 and day 3 PCT in predicting mortality.
Authors and Affiliations
Padmanaban Kandaswamy, Hemlata . , Gyan Prakash Singh, Mohammad Kaleem Ahmad
Keywords
Related Articles
- EP ID EP529632
- DOI 10.7860/JCDR/2018/37394.12185
- Views 78
- Downloads 0
Anti-C1q Antibody is Associated with Renal and Cutaneous Manifestations in Asian Indian Patients with Systemic Lupus Erythematosus
Introduction: C1q play an important role in clearance of immune complexes and apoptotic cell debris. Impaired clearance leads to exposure of C1 native antigen and development of antiC1q antibody formation. Anti-C1q antib...
Amiodarone Induced Fulminant Hepatotoxicity: A Case Report
ABSTRACT Amiodarone is an iodine-rich Class III antiarrhythmic drug, which acts via membrane ion channels. It is metabolised in the liver to produce the active metabolite desethylamiodarone. It is highly lipophilic with...
A 12-Week “Silver Yoga” Program Enhances Lung Function in Elderly Women Residents of a Hospice
ABSTRACT Introduction: “Silver Yoga” program has been devised by Centre for Yoga Therapy, Education and Research (CYTER) of Sri Balaji Vidyapeeth, Pondicherry. Participants practiced the protocol that was specially desig...
Evaluation and Comparison of Blood Parameters in Diabetic Patients with and without Peripheral Neuropathy
Introduction: Diabetic Peripheral Neuropathy (DPN) is the most prevalent and troublesome microvascular complication (50%) of Diabetes Mellitus (DM). The factors involved in the pathogenesis of diabetic neuropathy have no...
Carbamazepine Induced Thrombocytopenia
Antiepileptic Drugs (AEDs) are commonly associated with haematological disorders, including anaemia, thrombocytopenia, neutropenia and even bone marrow failure. Fatal disorders like aplastic anaemia are uncommon. On expl...