Comparative evaluation of Rosner’s index (ICA) Vs Chang’s (% correction) as a screening test (mixing study)
Journal Title: IP Journal of Diagnostic Pathology and Oncology - Year 2018, Vol 3, Issue 3
Abstract
Introduction It is difficult to interpretate mixing study results both screening confirmatory in presence of LAC The main objective of this study is to define cut off values for ICA Correction which will reduce the no of false positive negative cases will help in proper categorization of factor deficiency inhibitors This study also briefs about preanalytical errors their correctionMaterial and Methods Rosner Index Cut offs 10 Correction 15 InhibitorLatest Sysmex CS5100 autoanalyser was used to determine the Cutoffs DRVVT mixing test ratio Rosners index ICA 115 correction 10 DRVVT Normalised ratio NR 105 p value 015 is 911 sensitive for inhibitor diagnosis it could not categorise 8 of total cases into factor deficiency inhibitorDiscussion Rosners index ICA as a confirmatory test for LA is more sensitive than correction DRVVT NR Changs correction with a cut off value of 70 is 85 sensitive in diagnosing factor deficiency a cut off value of Conclusion It can be safely concluded that Rosner index is better than correction both as a screening test confirmatory test to differentiate factor deficiency from inhibitor This study results are in agreement with CLSI guidelines favours the sequential order screenconfirm then if required mixing study as in case of screen and confirm analysis is not clearcut andor when other causes of prolonged clotting times are known or suspected The draw back with the mixing studies is that weak LAC can be missed Though in this study Nijmegen is better than Bethesda in terms of sensitivity specificity as the later gives false positive results other studies has to be taken into consideration which shows that both the Bethesda Nijgmegen technique have low specificity at higher inhibitor titre If actual quantitation of high titre activity is required then it is more reliable to estimate empirically plasma dilution that gives 50 inhibitionKeywords Lupus anticoagulant Pooled normal plasma Mixing study Rosners Index Changs correction
Authors and Affiliations
Mirza Asif Baig, Anil K. Sirasagi
Keywords
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- EP ID EP482768
- DOI 10.18231/2581-3706.2018.0041
- Views 111
- Downloads 0
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