Comparative Evolution of Immune Enhancing Potentialof AlumandMPL asRabies Vaccine Adjuvants and Related Adverse Events
Journal Title: International Journal of Engineering and Science Invention - Year 2017, Vol 6, Issue 7
Abstract
Rabies is a preventable viral disease of mammals most often transmitted through the bite of a rabid animal. The vast majority of rabies cases reported to the Centers for Disease Control and Prevention(CDC). Rabies vaccine is an active immunizing agent used to prevent infection caused by the rabies virus. Alum and MPL are two adjuvantsenhance the immune response post vaccination. Therefore, the anti- rabies total IgG was evaluated to determine the immune response to alum and MPL adjuvanted and nonadjuvanted rabies vaccine. The adverse reactivity to the used alum and MPL adjuvanted rabies vaccine was considered via evaluation of its effect on liver regarding the apoptotic pattern via monitoring the cell cycleprofile,it was noticed that the cells were arrested during the G2/M phase post vaccination with both alum and MPL adsorbed vaccine.Sole vaccine administration showed an arrest during the G0-G1 Phase. Also, the apoptosis pattern of cell significantly elevated than negative control. Pathological changes related to administration of MPL adsorbed vaccines showed a significantpathological changes in liver and kidneytissues than those induced post administration of Alum adsorbed One. In the same time,pro-inflammatory mediators (IFN- γ and Il-6) were elevated post different vaccine formulae administration and their levels were time depended. Total IgG was significantly elevated in case of MPL adjuvanted vaccine than alum adsorbed and non- adsorbed one.
Authors and Affiliations
Mohamed Ayman Mohamed, Doaa Abd El Aziz Badr, Rania I. Shebl, Aly Fahmy Mohamed
Keywords
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