Comparative Hepatotoxic Effects of Aqueous and Phenolic Extracts of Avocado (Persea americana) Seed in Wistar Albino Rats
Journal Title: International Journal of Biochemistry Research & Review - Year 2016, Vol 10, Issue 4
Abstract
Aims: The present study was conducted to determine hepatotoxic effect of aqueous and phenolic extracts of Persea americana seed. Place and Duration of Study: Department of Biochemistry, Bayero University Kano, Nigeria. November 2012 to January 2013. Methodology: Wistar albino rats weighing 100 to 110 g were divided into four groups. The aqueous and phenolic extracts were administered orally for 21 days, at a dose of 500 mg/kg body weight. Blood samples were collected for the assessment of serum marker enzymes, while the liver tissue was used for histopathological Studies. Results: The serum levels of AST, ALT, and ALP in aqueous and phenolic extracts groups were found to be significantly higher compared to control group. However, group treated with solution of phenol shows no significant pathology. The Liver biopsy of aqueous and phenolic extracts treated rats shows severe degeneration of the hepatocytes when compared with control group, while group treated with solution of phenol shows little or no significant liver damage. Conclusion: The result suggested hepatotoxic effect of aqueous and phenolic extracts of Avocado seed, therefore administration of P. americana seed extracts may contribute significantly to liver damage, at higher dose.
Authors and Affiliations
Umar Abdullahi Zakariya, Umar Aliyu Umar, Sabiu Murtala Dambazau, Abdullahi Sulaiman
Keywords
Related Articles
- EP ID EP351170
- DOI 10.9734/IJBCRR/2016/23196
- Views 115
- Downloads 0
Assessment of Oxidative Stress and Lipid Status in Patients of Type 2 Diabetes Mellitus with and without Complications
Oxidative stress plays an important role in different disease processes. Some studies conducted on diabetic patients also support it. But very few studies have been conducted in the Indian subcontinent so far. Lipid pero...
Sensory Analysis of Dishes Based on Mucilages of Abelmoschus esculentus, Beilschmiedia mannii, Corchorus olitorius and Irvingia gabonensis from Côte d’Ivoire
Aims: The present work evaluates the sensory properties of culinary recipes based on mucilage extracted from mucilaginous food plants derived from the Ivorian flora. Study Design: MFPs edible parts were dried, mucilage w...
Production and Properties of Probiotic Soursop Juice Using Pediococcus pentosaceus LBF2 as Starter
Aims: Production of probiotic soursop juice and determination of properties of the juice samples for 3 weeks of storage at 4°C. Study Design: To determine the properties of soursop juice produced using Pediococcus pentos...
Evolution of the Pronostic Inflammatory and Nutritional Index (PINI) of the Malnourished Children of 6-59 Months during Supplementation with Soya and Spirulina in Côte d’ivoire
Aims: This study aimed to evaluate the evolution of the Pronostic of Inflammatory and nutritional Index (PINI) during the supplementation with soya and spirulina in children from 6 to 59 months. Study Design: Hundred ni...
Effect of Grinding Plates (GUK, Parpela and Premier) on Maize Flour Milled within Samaru, Nigeria
This research work was carried out to determine the concentration of Cu, Mn, Pb and Fe in maize flour milled by different types of milling plates in Samaru, Zaria, Nigeria. Three different types of milling plates with th...