Comparative Histopathological Effects of Metformin and Glibenclamide on Kidney in Alloxan Induced Diabetic Albino Rats
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 9
Abstract
Diabetes mellitus is a systemic metabolic disorder characterised by elevated blood glucose levels due to absolute or relative deficiency of insulin secretion from pancreatic β-cells. Clinically this disease is associated with a number of chronic complications including nephropathy, neuropathy, retinopathy, cardiovascular diseases and is responsible for causing impairment in kidney functions. Hence in this study we evaluated the histopathological effect of Metformin and Glibenclamide on kidney in Alloxan induced diabetic Albino rats.The present study was conducted on 24 experimental animals which were divided into four groups of with 6 rats in each group and were treated accordingly Group 1:Healthy control (HC) rats, Group 2:Diabetic control (DC) rats,Group 3:Diabetes mellitus (DM) + Metformin(M) rats, Group 4: Diabetes mellitus (DM)+ Glibenclamide(G) rats. After 28 days of treatment rats were sacrificed and histopathological study of kidney was done.Blood glucose and body weight was also determined.The results showed that both Metformin and Glibenclamide reversed Alloxan induced diabetic histopathological changes in kidney in Albino rats. The present Results demonstrate that normoglycemia with metformin and glibenclamide ameliorates diabetic induced histopathological lesions in kidney
Authors and Affiliations
Dr. Nuzhat Bashir, Dr. Aijaz Ahmad Patloo, Dr. Sabina Bashir
Keywords
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