COMPARATIVE HYPOGLYCEMIC AND NEPHROPROTECTIVE EFFECT OF TINOSPORA CORDIFOLIA AND METFORMIN ON ALLOXAN INDUCED DIABETIC MICE
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2017, Vol 3, Issue 3
Abstract
Diabetes mellitus, often simply referred to as diabetes, is a group of metabolic diseases in which a patient has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. This high blood sugar produces the classical symptoms of polyuria, polydipsia and polyphagia. It is characterized by hyperglycemia with disturbances in carbohydrate, lipid and protein metabolism resulting from defects in insulin secretion, insulin action or both. Experts estimate that diabetic population will grow from 195 to 360 million by 2030 almost 4.5 % of the global population. Present study Included biochemical parameters of mice. Four groups of mice were prepared for comparative study on control, diabetic, Tinospora cordifolia and Metformin. Diabetic models were prepared in mice by intraperitoneal administration of single dose of alloxan@120mg/kg b.w. Alcoholic extract of Tinospora cordifolia was administered @200 mg/kg b.w/day for four weeks. Metformin were administered @50 mg/kg b.w/day for four weeks. In diabetic group of mice glucose, urea, uric acid and createnine were increased. Effective restoration was observed in glucose, urea, uric acid and createnine of T. cordifolia administered group in comparison to metformin administered diabetic group of mice. kidney also shows effective restoration in T. cordifolia administered group of mice. Thus it is concluded from study that alcoholic extract of T.cordifolia restores glucose level to normal. Tinospora cordifolia acts effectively on diabetes mice as good as metformin on biochemical parameters.
Authors and Affiliations
Dr. Ranjit Kumar
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