Comparative In-Vitro Quality Evaluation of Commercially Available Atorvastatin Tablets in Bangladesh
Journal Title: Galore International Journal of Health Sciences and Research - Year 2018, Vol 3, Issue 4
Abstract
The aim of the present investigation was to evaluate the in vitro quality assessment of different marketed brands of Atorvastatin tablets (10mg) available in Bangladesh. Three brands of Atorvastatin tablets were selected and marked as A, B and C. Some quality control tests were performed such as weight variation test, friability test, hardness test, disintegration time, dissolution profile, potency test etc. to assess the quality level of these marketed products. All the brands complied with the official specification for weight variation and friability (below1%). According to the USP specification, disintegration time should be within 30 minutes which is maintained by all of these brands. Specification for the dissolution time of Atorvastatin is 90% or more in 45 minutes. Drug Release of Brand A, Brand B and Brand C were 99.49 %, 99.35%, and 101.06% respectively in 45 minutes. So according to specification all the brands are in acceptable range which indicated the quality products of Bangladeshi pharmaceuticals.
Authors and Affiliations
Kh M Nuruzzaman
Keywords
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