COMPARATIVE PHYTOCHEMICAL ANALYSIS OF MORINGA OLEIFERA (MORINGACEAE) EXTRACTS AND REPRODUCTIVE EFFECTS OF THE AQUEOUS LEAF, SEED AND BARK EXTRACTS IN RATS
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 5
Abstract
Moringa oleifera (moringa) is widely consumed for its several nutritional and medicinal benefits. This study analysed phytochemical constituents (alkaloids, flavonoids, tannins, anthraquinones, cardiac glycosides, carbohydrates, and saponins) of crude aqueous and ethanol extracts of leaf, seed, flower, bark and root of the plant collected from the southern part of Nigeria. The study also evaluated the effect of 21 days administration of different concentrations of the aqueous seed or bark extract (100, 200 and 400 mg/kg bwt) on sperm parameters using Wistar albino rats. The study additionally investigated the outcome of pregnancy when the aqueous leaf extract (200 mg/kg bwt) was administered from GD1 or GD7 till delivery in Wistar rats. All phytochemical compounds tested positive only in the flower (aqueous and ethanol), leaf (ethanol) and bark (ethanol) extracts. Overall, the ranking of phytoconstituents in the plant parts was: flower>seed>leaf>root>bark. There was reduction (p<0.05) of sperm motility in aqueous seed or bark extracts treated rats, but no changes occurred in their sperm count and morphology when compared with control. Maternal body weight was not affected by the leaf extract, neither did it alter gestation period, number of pups delivered or birth weight of pups, but successful pregnancy rate was reduced. In conclusion, the flower may contain more phytochemical compounds than other parts, whereas the bark the least. In addition, moringa seed or bark may reduce sperm motility without affecting count and morphology, while the leaf may induce pregnancy loss in rats.
Authors and Affiliations
Jonah Sydney Aprioku
Keywords
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COMPARATIVE PHYTOCHEMICAL ANALYSIS OF MORINGA OLEIFERA (MORINGACEAE) EXTRACTS AND REPRODUCTIVE EFFECTS OF THE AQUEOUS LEAF, SEED AND BARK EXTRACTS IN RATS
Moringa oleifera (moringa) is widely consumed for its several nutritional and medicinal benefits. This study analysed phytochemical constituents (alkaloids, flavonoids, tannins, anthraquinones, cardiac glycosides, carboh...