Comparative studies on Conventional -Microwave assisted synthesis of 2-azetidinone derivatives
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
A series of 2-Azetidinone (3a-3f) were synthesized, the structure of these new derivatives were confirmed using spectral methods starting from Hydrazide derivative of Ketoprofen ethyl ester a Schiff bases were synthesized using different aromatic aldehydes in ethanol which prepared by the conventional and the microwave methods then Determination of the Microwave optimum conditions for Schiff bases synthesis, and the final compounds were obtained by cyclocondensation using chloroacetylechloride also by the conventional and the microwave method then Determination Microwave optimum conditions for the final compounds synthesis. The synthesis of the designed compounds has been successfully achieved. Purity and characterization were confirmed by determination of physical properties (melting points & Rf values), FT-IR spectroscopy and1H-NMR Sp.
Authors and Affiliations
Ammar Ihsan MahmoodHelmi, Monther Faisal Mahdi *, Rafah Fadhel Al-Smaism
Keywords
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- EP ID EP390287
- DOI 10.9790/3008-1204065664
- Views 53
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