COMPARATIVE STUDY AND EVALUATION OF EFFICACY AND ACCEPTABILITY OF TWO REGIMENS WITH DIFFERENT TIME INTERVALS BETWEEN MIFEPRISTONE AND MISOPROSTOL FOR FIRST TRIMESTER MTP
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 19
Abstract
BACKGROUND Unsafe abortions are a major cause of maternal morbidity and mortality. Medical abortion, which is preferred over surgical abortion by most women may provide excellent alternative to unsafe abortion and their attendant risks. The primary aim of this research is to compare the efficacy and acceptability of two regimens with different time interval between mifepristone and misoprostol for first trimester MTP. MATERIALS AND METHODS The study was carried out in 150 pregnant women opting for MTP during first trimester by medical method. Pelvic ultrasound was done before giving drugs to assess the correct gestational age, intrauterine location of pregnancy and to exclude any obvious pelvic pathology. Women enrolled in the study were randomized to one of the two groups which differ in the time of administration of misoprostol. All 150 women were given Mifepristone 200mg on Day 1. However, 75 women in the study group were given misoprostol 600mcg on Day 2 and remaining 75 women in the control group were given misoprostol 600mcg on Day 3. The effects regarding efficacy, induction abortion interval, side effects and acceptability of two regimens were noted. RESULTS 1) 98.66% cases in study group and 94.66% in control group had successful abortions (p value>0.05) 2) 94% of cases preferred 24 hours study protocol rather than established protocol of 48 hours for any future MTP (p value < 0.02). CONCLUSION The research work helps to derive a conclusion that medical abortion using misoprostol administration 24 hours after mifepristone appears to be equally efficacious and more acceptable than that of the established protocol of 48 hours.
Authors and Affiliations
Niti Kautish, Anita Kant
Keywords
Related Articles
- EP ID EP557401
- DOI 10.18410/jebmh/2018/323
- Views 72
- Downloads 0
OUTCOME IN PATIENTS OF CERVICAL SPONDYLOTIC MYELOPATHY, ANTERIOR VERSUS POSTERIOR APPROACH- A RETROSPECTIVE ANALYSIS
BACKGROUND Cervical spondylotic myelopathy is a complex multi-factorial disease process having both metabolic and biomechanical factors. The choice of the surgical approach, whether anterior or posterior, is determined b...
CUMMULATIVE EFFECT OF INCISIONAL INFILTRATION IN ADDITION TO WOUND INSTILLATION, AMONG TWO SESSIONS OF TUMESCENT ANALGESIA IN POSTOPERATIVE MODIFIED RADICAL MASTECTOMY (MRM) PATIENTS
AIMS: This study was conducted to evaluate and compare the efficacy of two sequential sessions of tumescent analgesia in modified radical mastectomy patients for immediate postoperative pain relief. MATERIALS AND METHODS...
DOPPLER ASSESSMENT OF THE AORTIC ISTHMUS AND ITS UTILITY IN MANAGEMENT OF INTRAUTERINE GROWTH RESTRICTED FOETUSES
BACKGROUND Cardiovascular Doppler indices have long been demonstrated to have an association with the risk of perinatal death. Recent studies have investigated whether the aortic isthmus (AoI) could contribute to the pre...
ASSESSING THE IMPORTANCE OF BREAST SELF EXAMINATION AND BREAST CANCER AWARENESS AMONG HEALTH CARE PROFESSIONALS
INTRODUCTION: Breast cancer appears to be a disease of both developing and developed country. Breast cancer is now the most common cancer in most cities in India, and 2nd most common in the rural areas. OBJECTIVES: 1. To...
TO STUDY THE EFFECT OF HYPERGLYCAEMIA IN TRAUMATIC BRAIN INJURY
BACKGROUND Traumatic brain injury (TBI) is the most common cause of mortality in the young- and middle-aged group in developing countries. As there is an increasing incident of type 2 diabetes mellitus, it plays an impor...