COMPARATIVE STUDY BETWEEN INCLUSION COMPLEX WITH HYDROXYPROPYL-β-CYCLODEXTRIN AND NANOCRYSTAL TECHNOLOGY FOR ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF POORLY SOLUBLE DRUG ALBENDAZOLE
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 1
Abstract
The aim of the present work was to enhance solubility and dissolution rate of albendazole a class II drug by two different techniques and compare them for improved drug delivery study. These techniques are inclusion complex of albendazole with Hydroxypropyl-β-Cyclodextrin (HP-β -CD) and converting drug into nanocrystal by anti solvent precipitation technique in the presence of sodium lauryl sulfate as stabilizer. HP-β-CD molecules are cone-shaped with hydrophobic central cavity and hydrophilic outer surface and are capable of forming inclusion complexes with drug by taking up a whole drug molecule or some hydrophobic part of it, into the cavity and there by enhance the drug dissolution and solubility. Nanocrystals are new carrier free colloidal drug delivery system with nano sized particles below 1000 nm, and considered as a great drug delivery technique to enhance the drug dissolution and solubility. In the present work the drug inclusion complex with HP-β -CD were prepared by kneading technique with different ratios of HP-β-CD. All formulations showed marked improvement in dissolution and solubility compared to pure drug. Drug nanocrystals were prepared by anti solvent precipitation technique. Different concentrations of sodium lauryl sulphate (SLS) as stabilizers were evaluated. All formulations were in the nano size and showed marked improvement in dissolution and solubility compared to pure drug of micron size. Finally it was concluded that formulating poorly soluble drugs in the form of nanocrystals would be a promising approach in delivery of class II drugs by oral route in a simple and effective way.
Authors and Affiliations
Chaudhari Bharat*| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, India., Asija Rajesh1| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, India., Asija Sangeeta| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, India., Patel Chirag J| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, India., Patel Pinkesh| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, India., Patel Jaimin| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, India.
Keywords
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