Comparative Study between Serum and Salivary Cortisol Levels to Assess Adrenal Cortisol Insufficiency in Patients with Cirrhosis
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 1
Abstract
The reduction in the synthetic function of the liver in patients with liver cirrhosis makes measuring of total serum cortisol invalid because of the prevalence of hypoalbuminemia and the decreased level of cortisol binding globulin in these patients. Salivary cortisol concentrations accurately reflect the free cortisol level in non cirrhotic patients because the unbound portion of cortisol in the blood freely diffuse into saliva which represent the fraction which diffuses to the target tissues of the body. Aims: To study the correlation between salivary, serum total cortisol and calculated free cortisol. The prevalence of cortisol insufficiency using salivary and serum assays. Parameters associated with the discrepancy between both tests in cirrhotic patients. Methods: Fasting serum cortisol was assessed using ADVIA Centur Autoanalizer together with salivary cortisol using Salimetrics Salivary assay kit cat. #1-3002 5pk 1—32002-5-USA at 8 AM. Pituitary hypoadrenalism will be excluded in patients with total cortisol level less than 4 µg/ dl. Results: Salivary cortisol and calculated free cortisol are significantly correlated to adrenal function in cirrhotic patients more than serum total cortisol. Conclusion: Salivary cortisol levels are the most accurate to asses adrenal cortical function in cirrhotic patients.
Authors and Affiliations
Amr A. bdel Moety
Keywords
Related Articles
- EP ID EP213141
- DOI -
- Views 72
- Downloads 0
Autoimmune Encephalitis-A Rare Case Report
Patient 29/ Female admitted with complaints of fever with chills, altered sensorium and nausea since 2 days. Complete fever profile negative.MRI CSF studies done normal. Patient throwed focal seizures with general examin...
Ultrasonographic Evaluation of Acute Abdomen In Children
Acute abdomen is a medical emergency, in which there is sudden and severe pain in abdomen of recent onset with accompanying signs and symptoms that focus on an abdominal involvement. It can represent a wide spectrum of c...
Congenital Alveolar Proteinosis, A Straight Forward Diagnosis But Often Missed: A Case Report
We report an infant who presented with respiratory distress soon after birth. After exhaustive workup including histopathalogy and electronmicroscopy of the excision biopsy specimen of the lung, infant was finally diagno...
Congenitally Fused Kidney Mal-Positioned In the Sacral Region
Normally the anatomical position of kidneys is at the level of T12-L3 vertebrae in relation to spine. It is supplied by renal artery which is a branch of abdominal aorta.
Relationship between Body Mass Index and Body Fat Percentage
Background; Obesity is a worldwide epidemic. According to the latest reports India is the third most obese country in the world. Obesity is a condition with excess body fat to the extent that health and wellbeing are adv...