Comparative Study Between Sublingual and Vaginal Misoprostol for Induction of Labor in Post Term Pregnant Patients with Unfavourable Cervix
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 6
Abstract
<strong>Background: </strong>Pharmacological studies suggest that sublingual route might be the optimal route of administration for PGE1 analogue misoprostol because the avoidance of the first pass hepatic circulation would yield bioavailability like that achieved with the vaginal route along with an earlier onset of action and a prolonged activity. <strong>Objective: </strong>The aim of this study was to compare the efficacy and the safety of vaginal misoprostol with sublingual misoprostol for induction of labor in post-term pregnancy. <strong>Subjects and Methods: </strong>This study included 50 cases, each with a singleton post-term pregnancy and a live fetus requiring induction of labor were allocated to sublingual and vaginal administration of misoprostol. Outcome measures related to labor and maternal and fetal side effects were compared between the 2 groups and evaluated using Chi square test. <strong>Results: </strong>The sublingual route of misoprostol was associated with a reduced risk of failed induction, reduced time from initiation to induction, reduced induction to delivery interval and a higher incidence of maternal and fetal side effects. However, the differences were not statistically significant. <strong>Conclusion: </strong>The sublingual route of administration of misoprostol is comparable in efficacy and safety to the vaginal route for induction.
Authors and Affiliations
Eman Helal
Keywords
Related Articles
- EP ID EP584229
- DOI 10.12816/ejhm.2018.9845
- Views 94
- Downloads 0
The Role of Tonsillectomy in the Treatment of Obstructive Sleep Apnea
Background: Obstructive Sleep Apnea (OSA) is caused by a partial or complete obstruction of the upper airway. OSA is a very inconvenient and relatively common disorder with daytime and nocturnal symptoms. The interventio...
A 6-Year-Old Saudi Boy with Myotonia Congenita
<strong>Background:</strong> myotonia congenita is an inherited form of myotonia that is due to mutations in the skeletal muscle chloride channel CLCN1. These mutations lead to reduced sarcolemmal chloride conductance, c...
Effect of General Anesthesia versus Spinal Anesthesia in Cesarean Section on Regain of Gastrointestinal Motility
Background: cesarean section is a common major hospital surgical procedure performed nowadays. One of the most common postoperative complications is postoperative gastrointestinal paralysis (Ileus) that must be minimized...
Is Neutrophil/Lymphocyte Ratio A Useful Marker to Predict the Severity of Pre-Eclampsia?
Background: Preeclampsia refers to the new onset of hypertension and proteinuria or hypertension and end-organ dysfunction with or without proteinuria after 20 weeks of gestation in a previously normotensive woman. Objec...
Study of Structural Changes in Diabetic Macular Edema by Spectral Domain Optical Coherent Tomography after Intravitreal Injection of Triamcinolone Acetonide
<span>Purpose: </span><span>is to study the morphological changes in Diabetic Macular Edema (DME) before and after intravitreal injection of triamcinolone acetonide using the spectral domain</span><span>–</span><span>opt...