Comparative Study Between Sublingual and Vaginal Misoprostol for Induction of Labor in Post Term Pregnant Patients with Unfavourable Cervix
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 6
Abstract
<strong>Background: </strong>Pharmacological studies suggest that sublingual route might be the optimal route of administration for PGE1 analogue misoprostol because the avoidance of the first pass hepatic circulation would yield bioavailability like that achieved with the vaginal route along with an earlier onset of action and a prolonged activity. <strong>Objective: </strong>The aim of this study was to compare the efficacy and the safety of vaginal misoprostol with sublingual misoprostol for induction of labor in post-term pregnancy. <strong>Subjects and Methods: </strong>This study included 50 cases, each with a singleton post-term pregnancy and a live fetus requiring induction of labor were allocated to sublingual and vaginal administration of misoprostol. Outcome measures related to labor and maternal and fetal side effects were compared between the 2 groups and evaluated using Chi square test. <strong>Results: </strong>The sublingual route of misoprostol was associated with a reduced risk of failed induction, reduced time from initiation to induction, reduced induction to delivery interval and a higher incidence of maternal and fetal side effects. However, the differences were not statistically significant. <strong>Conclusion: </strong>The sublingual route of administration of misoprostol is comparable in efficacy and safety to the vaginal route for induction.
Authors and Affiliations
Eman Helal
Keywords
Related Articles
- EP ID EP584229
- DOI 10.12816/ejhm.2018.9845
- Views 99
- Downloads 0
Knowledge, Attitude and Practice of Family Planning Methods among Husbands in a Village of Assiut Governorate
<strong>Background:</strong> husbands usually are the decision makers about sexual activity, and the desired number of children. They often know very little about the health benefits of planning and spacing pregnancies....
Comparison between volume-controlled and pressure-controlled ventilation in COPD patients undergoing laparoscopic cholecystectomy
<strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is a well-known independent risk factor for the development of postoperative pulmonary complications. Managing ventilation and oxygenation during...
Renal Stones among Adult Population in Arar City, Northern Saudi Arabia
<span>Background: </span><span>Renal stone is a major health problem with adverse medico-economic consequences. It cost the healthcare services a great deal of money without reaching any desired destiny. </span><span>Obj...
Role of S-Iron and Ferritin to Predict the Response to Recent New Antiviral Treatment in Chronic Hepatitis C Patients
<strong><span lang="EN-US">Background: </span></strong><span lang="EN-US">Chronic hepatitis C (CHC) is an important liver disease, which may progress to cirrhosis or hepatocellular carcinoma. The current treatment regime...
Evaluation of Patients with Iron Deficiency Anemia
<strong>Objectives: </strong>We aimed to assess the effect of anemia on subjective sleep quality in patients with iron deficiency anemia (IDA). <strong>Methods: </strong>The present study is a prospective and cross-secti...