Comparative Study of 3% Hypertonic Saline Nebulisation Versus 0.9% Normal Saline Nebulisation for Treating Acute Bronchiolitis
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 6
Abstract
ABSTRACT Introduction: Bronchiolitis is commonly noticed condition in children, especially in infants and characterised by inflammation of bronchioles. Inspite of this common occurrence the evidence for the treatment options is limited. Aim: To compare the effect of 3% Hypertonic Saline (HS) nebulisation with 0.9% Normal Saline (NS) nebulisation for treating acute bronchiolitis in moderately ill hospitalised infants and children (<18 months) on Length Of Hospital Stay (LOS) and improvement in clinical severity score. Materials and Methods: This is a randomised controlled trial, done in a tertiary care paediatric hospital over a period of one year from April 2014 to March 2015. Out of 189 children randomised, 96 patients and 93 patients received HS nebulisation and NS nebulisation respectively. Treating doctors and patients were blinded to intervention and outcome. Results: Reduction in clinical severity score in 3% HS nebulisation group was 2.26 (0.684) and in 0.9% NS nebulisation group was 1.23 (0.492), with statistically significant p<0.001. LOS in 3% HS nebulisation group was 1.45 (0.540) days and in 0.9% NS nebulisation group was 2.35 (0.619) days with mean difference of 0.91 (0.084) day with statistically significant p<0.001. Conclusion: This study demonstrates that 3% HS nebulisation is safe and effective treatment for infants up to the age of 18 months hospitalised with acute bronchiolitis and decreases hospital stay by about one day.
Authors and Affiliations
Tanveer Bashir, Kallem Venkat Reddy, Kaiser Ahmed, Saima Shafi
Keywords
Related Articles
- EP ID EP524619
- DOI 10.7860/JCDR/2018/34766.11594
- Views 58
- Downloads 0
Histogenesis of Thyroid Gland in Dead Human Foetuses of Different Gestational Age
ABSTRACT Introduction: In human beings the thyroid gland is one of the largest differentiated endocrine gland. The function of thyroid gland is to promote growth and development of the brain during foetal life and for t...
Dasatinib Induced Cardiac TamponadeA Rare Association
Drug induced cardiac tamponade is rare. Therapy for imatinib resistant Chronic Myeloid Leukaemia (CML) is an emerging challenge in clinical haematology. For such cases treatment with second line tyrosine kinase inhibitor...
Morel-Lavallee Lesion: Case Report with Review of Literature
Morel-Lavallee lesions are closed degloving soft tissue injuries which occur because of trauma and in which the skin and subcutaneous tissue are separated from superficial fascia. This shear trauma results in creation of...
Effect of Atorvastatin on Glycaemic Parameters in Normoglycaemic and Prediabetic Subjects: A Prospective, Panel Study
Introduction: Type 2 diabetes is associated with obesity and dyslipidemia, which are risk factor for cardiovascular disease. With recent FDA approved indications for statins being widened because of its lipid lowering an...
Diagnostic Yield of Post-mortem Needle Biopsies and their Spectrum: Experience from a Tertiary Care Hospital
ABSTRACT Introduction: Conventional autopsy provides important information regarding cause of death, clinico-pathological correlation and is a paramount source of learning. Developing countries have low acceptance rates,...