Comparative Study of 3% Hypertonic Saline Nebulisation Versus 0.9% Normal Saline Nebulisation for Treating Acute Bronchiolitis
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 6
Abstract
ABSTRACT Introduction: Bronchiolitis is commonly noticed condition in children, especially in infants and characterised by inflammation of bronchioles. Inspite of this common occurrence the evidence for the treatment options is limited. Aim: To compare the effect of 3% Hypertonic Saline (HS) nebulisation with 0.9% Normal Saline (NS) nebulisation for treating acute bronchiolitis in moderately ill hospitalised infants and children (<18 months) on Length Of Hospital Stay (LOS) and improvement in clinical severity score. Materials and Methods: This is a randomised controlled trial, done in a tertiary care paediatric hospital over a period of one year from April 2014 to March 2015. Out of 189 children randomised, 96 patients and 93 patients received HS nebulisation and NS nebulisation respectively. Treating doctors and patients were blinded to intervention and outcome. Results: Reduction in clinical severity score in 3% HS nebulisation group was 2.26 (0.684) and in 0.9% NS nebulisation group was 1.23 (0.492), with statistically significant p<0.001. LOS in 3% HS nebulisation group was 1.45 (0.540) days and in 0.9% NS nebulisation group was 2.35 (0.619) days with mean difference of 0.91 (0.084) day with statistically significant p<0.001. Conclusion: This study demonstrates that 3% HS nebulisation is safe and effective treatment for infants up to the age of 18 months hospitalised with acute bronchiolitis and decreases hospital stay by about one day.
Authors and Affiliations
Tanveer Bashir, Kallem Venkat Reddy, Kaiser Ahmed, Saima Shafi
Keywords
Related Articles
- EP ID EP524619
- DOI 10.7860/JCDR/2018/34766.11594
- Views 92
- Downloads 0
Evaluation of Visual Outcomes of Cataract Surgery in Diabetic Patients and Assessment of Post-operative Complications as Compared to Non-diabetics
ABSTRACT Introduction: A leading cause of vision loss in the young adult population worldwide is sequelae and complications of diabetes. Cataract surgery performed on diabetic patients accounts for approximately 20% of t...
Prevalence of Dental Caries in India among the WHO Index Age Groups: A Meta-Analysis
ABSTRACT Introduction: Dental caries is widely prevalent globally but the distribution and severity of dental caries varies across countries and regions. In the absence of surveillance or real time monitoring of dental c...
Role of Cross Sectional Imaging in Isolated Chest Wall Tuberculosis
Introduction: Isolated chest wall tuberculosis though a rare entity, the incidence of it has been on rise among immunocompromised population making it an important challenging diagnosis for the physicians. Its clinical p...
Revisiting Nitrofurantoin for Vancomycin Resistant Enterococci
Introduction: Enterococcal infection has emerged as a major therapeutic challenge. Emergence of High Level Aminoglycoside Resistance (HLAR) and Vancomycin-Resistant Enterococcus (VRE) has further limited the drug therapy...
Comparative Evaluation of Serum Malondialdehyde (MDA) Level in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma
ABSTRACT Introduction: Lipid peroxidation, which is induced by reactive oxygen species, is involved in the pathogenesis of malignancy. This lipid peroxidation levels are indicated by Malondialdehyde (MDA), which is the m...