COMPARATIVE STUDY OF ANTI-INFLAMMATORY ACTIVITY OF NEWER MACROLIDES WITH ETORICOXIB
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2014, Vol 3, Issue 10
Abstract
The present study was designed to investigate the anti-inflammatory activity of macrolides and to compare with standard non- steroidal anti-inflammatory drug (NSAID) etoricoxib. This study was conducted in male wistar albino rats by inducing edema with 1% carrageenan. Animals were divided into 5 groups with 6 in each and paw edema volume was measured by digital plethysmograph before and 3hrs after 1% carrageenan administration. Percentage of inhibition of paw edema was calculated. Results showed macrolides having significant anti-inflammatory activity & the anti-inflammatory activity of roxithromycin was almost equally comparable with etoricoxib.
Authors and Affiliations
Gajendra naidu, Madhavi E, Venu Konda, Venkata Ramana, Rajeshwaramma G
Keywords
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- EP ID EP101003
- DOI 10.14260/jemds/2014/2153
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