COMPARATIVE STUDY OF ANTIMICROBIAL ACTIVITY OF CEFTRIAXONE IN COMBINATION WITH SULBACTAM AND TAZOBACTAM USING DISC DIFFUSION METHOD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
The present study includes comparative analysis of the antimicrobial effect of combination of ceftriaxone/sulbactam and ceftriaxone/tazobactam against Staphylococcus aureus (S. aureus). Isolate of β-lactamase producing S. aureus was cultured. Antibiotic discs of ceftriaxone/sulbactam and ceftriaxone/tazobactam combinations were prepared and their antimicrobial activity was compared against zone of inhibition produced in cultured isolates. National Committee for Clinical Laboratory Standards zone diameter criteria was used to measure and evaluate the diameter of zones of inhibition. Zones of inhibition produced by ceftriaxone/tazobactam combination were larger than those produced by ceftriaxone/sulbactam combination indicating comparative advantages. The study reveals that as compared to sulbactam, tazobactam is adding more synergistic action to the ceftriaxone activity against S. aureus.
Authors and Affiliations
Himanshu Rajpurohit , Vinay Kumar , KC Sharadamma , PM Radhakrishna
Keywords
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