Comparative Study of Antioxidant Activity and Hepato-Protective Effect of Extracts of Tetracarpidiumconophorumand Dacryodesedulison Sodium Arsenate Exposed Rats
Journal Title: Saudi Journal of Biomedical Research - Year 2018, Vol 3, Issue 2
Abstract
Abstract:This study comparatively evaluated the in vitro antioxidant activity and the hepato-protective effect of extracts of two locally consumed fruits, Dacryodesedulis(African pear) and Tetracarpidiumconophorum (African walnut) in sodium arsenate exposed rats. Antioxidant activity was determined by spectrophotometric methods using 2, 2-diphenyl-2- picrylhydrazyl (DPPH) radical, hydrogen peroxide (H2O2) and malondialdehyde (MDA) assays. Total phenol, flavonoids and anthocyanins content of extracts were also determined. Results from the study indicated that DPPH and H2O2 scavenging capacity as well as percentage inhibition of MDA were significantly higher (P˂0.05) in extract of T. conophorum(48.34%, 46.9% and 53.5%, respectively) when compared with D. edulisextract (45.47%, 18.1% and 45.3%, respectively). The anthocyanins content was significantly higher (P˂0.05) in D. edulisextract than inT. conophorum. Whereas, T. conophorumextract recorded higher phenol content (52.3GAE/100g) compared withD. edulis extract (22.5GEA/100g). The flavonoids content of T. conophorum extract was comparable to that of D. edulis. The hepato-protective effects of the extracts were examined in vivo in male Wister rats challenged with sodium arsenate. Results showed that the rats fed with the two extracts had significant reduction (p<0.05) in lipid peroxidation, increase in SOD and catalase activities relative to control values. These results suggest that rat fed with Dacryodesedulisand Tetracarpidiumconophorumextracts possess varied degree of potent antioxidant activity and may serve as important sources of antioxidants in food, cosmetics and pharmaceutical industries. Keywords:Dacryodesedulis, Tetracarpidiumconophorum, antioxidants, sodium arsenate, hepato-protective.
Authors and Affiliations
Uhunmwangho ES, Omoregie ES
Keywords
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