Comparative Study of Antioxidant and Anticancer Activity of Thuja orientalis Growing in Egypt and Saudi Arabia
Journal Title: Journal of Pharmaceutical Research International - Year 2017, Vol 15, Issue 5
Abstract
Cancer is a life threatening diseases, caused by many factors including the oxidative stress. Some medicinal plants are rich with volatile oil represent an important source of antioxidant and anticancer drugs. This study explored the compositions of the essential oils of the flowering aerial parts of Thuja orientalis (cupressaceae) and evaluated antioxidant and cytotoxic activity against different tumors cell lines. The compositions of the essential oils obtained by hydro-distillation of the flowering aerial parts was determined by GC-MS analysis, the antioxidant activities of essential were determined by DPPH radical scavenging method and, In-vtro cytotoxic activities were evaluated against different tumors cell lines, MCF7 (breast carcinoma cell line), PC3 (human prostate carcinoma), HCT116 (human colon carcinoma), A549 (lung carcinoma cell line), and Hep-G2 (liver carcinoma cell line), by the MTT method. The results showed that essential analyzed sample, very rich in Phellandrene, Terpenyl acetat, and β -Caryophyllene with high amounts. The results showed that essential oil extracted from Saudi plant exhibited higher antioxidant activity. Saudi oil extract also possess highest cytotoxic activities against MCF7, followed by, PC3 and, Hep-G2 while the least activity was recorded against lung carcinoma cell line. The highest antioxidant and cytotoxic activity of Thuja plant growing in Saudi Arabia were correlated with its high content of some compounds which are rich in Saudi plant and absence in Egyptian plant. These findings revealed that plant in two regions could be considered as a great potential source for natural health products, where Saudi plant more adapted to drastic condition by accumulation of higher amount of essential oil.
Authors and Affiliations
Eman Ramadan Elsharkawy, Haya Aljohar, Abd El Raheim M. Donia
Development of Anti-bacterial Ointment from Two Extracts of Curcuma longa L. and Aloe vera L.
Aim of this Study: This study aimed to extract, formulate and evaluate an antibacterial ointment from extracts of two Yemeni plants. Methods: The extraction of both Curcuma longa and Aloe vera was performed using alcohol...
Bersama abyssinica Fresen. (Melianthaceae): Antifungal Activity on Aflatoxin B1-producing Mold
Aspergillus flavus is the main aflatoxin-producing mold (only group B). In view of the extent of the pathologies caused by these toxins, we have begun a series of research on medicinal plants with the aim of finding new...
Development and Evaluation of Ophthalmic Drop and In-situ Gel from Roots of Boerhaavia diffusa
The present investigation deals to evaluate efficacy of ophthalmic drop and in-situ gel formulations of aqueous distillate of Boerhaavia diffusa roots using polymers sodium alginate (SA), HPMC (hydroxyl propyl methyl cel...
Biosimilar mAb in-process Sample Higher Order Structure Analysis with Protein Conformational Array ELISA
Biologics higher order structure (HOS) plays an important role in the molecule’s biological function and is closely related to its immunogenicity property. A novel technology to study changes in HOS is the Protein Confor...
Assessment of Organ Damage Markers in Acetaminophen-induced Hepatotoxicity in Rats Pre-treated with Quail Eggs
This study investigated the response of organ damage markers to quail egg pre-treatment on acetaminophen–induced hepatotoxicity in rats. Thirty (30) albino wistar rats assigned to 5 groups of 6 rats each were used for th...