Comparative study of clinical and functional outcome between the efficacy of platelet rich plasma and hyaluronic acid injection in osteoarthritis of knee joint
Journal Title: International Journal of Orthopaedics Sciences - Year 2018, Vol 4, Issue 1
Abstract
Introduction: Platelet rich plasma (PRP), a blood-derived product rich in growth factors, is a treatment for cartilage defects. PRP's use is limited due to the lack of clinical evidence. Various studies have suggested that an injection of hyaluronic acid (HA) provides better results in early osteoarthritis. Purpose: We aimed to compare clinical and functional outcomes of using hyaluronic acid versus platelet rich plasma in the treatment of osteoarthritis of the knee joint. Methods: 60 patients were included in the study. 30 were treated with HA and the other 30 with PRP. The patients were evaluated 6 months after the procedure. Patients were evaluated before and after the procedure using Visual Analogue Scale (VAS) and Western Ontario McMaster Universities Osteoarthritis Index (WOMAC). Range of motion was measured over time. Adverse events and patient satisfaction were also recorded. Results: Both groups presented a clinical improvement but significantly better results were seen in the group of patients receiving PRP injections as indicated by their WOMAC and VAS scores at a 12 week and 24 week follow-up. No severe adverse events were observed. Mild pain and effusion after the injection was seen in the PRP group. Conclusions: Our preliminary findings support the application of autologous PRP as a safe and effective method in the treatment of the initial stages of knee osteoarthritis. Significant clinical improvement was seen with 6 months of follow-up. More promising results need to be obtained in order to use it for low grade degeneration.
Authors and Affiliations
Varun GBS, Vignesh Kumar V, Raj Lavadi, Muralidhar N
Keywords
Related Articles
- EP ID EP485948
- DOI 10.22271/ortho.2018.v4.i1p.153
- Views 100
- Downloads 0
Study of role of prosthetic replacement for comminuted fracture of head of radius
Objective: We had evaluated our experience in the treatment of Morrey Modified Masons type III and IV radial head fractures with radial head prosthesis. Materials and Methods: From April 2014 to September 2017, modular r...
Functional outcome of orthogonal plating in treatment of distal humerus fracture
Background: The study was conducted to evaluate the outcome of orthogonal plating system in distal humerus intraarticular fracture. Material and Methods: 15 patients of age between 18 to 60 yrs with fracture distal end...
MIPO with anatomical plate for distal tibia extra articular fractures: A safe and effective modality
Background: Distal tibia fractures are often amongst the most difficult fractures to treat because of the hour glass shape of the distal tibia poses a difficulty to achieve fixation with intramedullary nails. Surgical ma...
Paratricepital approach for fixation of distal humerus fracture in adults - A good alternative
Objective: Distal humerus fractures most commonly managed by surgical approaches that disrupt the extensor mechanism of elbow. Paratricepital posterior approach for distal humerus fracture fixation done by orthogonal or...
Short term outcome of arthroscopic single bundle ACL reconstruction using quadruple hamstring graft by transportal technique for complete ACL tear
Objective: To study short term outcome of arthroscopic single bundle ACL reconstruction using quadruple hamstring graft by transportal technique. Introduction: Arthroscopic ACL reconstruction is the ‘Gold Standard’ treat...