Comparative Study of Clomiphene Citrate and Aromatase Inhibitors (Short and Long Protocols) In Polycystic Ovarian Syndrome
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 7
Abstract
Background: Polycystic ovarian syndrome (PCOS) is a heterogenous disorder and is characterized by excessive androgen production by the ovaries.First line drug for ovulation induction is clomiphene citrate(CC).Insufficient evidence is currently available to recommend the clinical use of aromatase inhibitors for routine ovulation induction. Methods: It was the prospective study of 120 women between 20 -35 years of age who are PCOS with regular follow up in OPD. They were divided into three study groups on the basis of drugs used. Results: Ovulation was better in women on clomiphene citrate and letrozole 5 mg short protocol as compared to women on letrozole 2.5mg long protocol. Conclusions: The rate of ovulation with clomiphene citrate (group A) in PCOS patients is 76% and with letrozole short (group B) and long protocols(group C) it is 64% and 28.8% respectively.The endometrial thickness in clomiphene citrate(group A) in PCOS patients is 8.8 mm and with letrozole short(group B) and long protocol(group C) in PCOS patients it is 10 mm and 10.2 mm respectively
Authors and Affiliations
Swati Garg
Keywords
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