COMPARATIVE STUDY OF DIFFERENTIAL EXPRESSION OF CYCLIN-E IN NORMAL PLACENTA, HYDROPIC ABORTUS AND GESTATIONAL TROPHOBLASTIC DISEASE
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 35
Abstract
BACKGROUND Gestational Trophoblastic Disease (GTD) encompasses a heterogeneous group of lesions, characterised by proliferation of pregnancy associated trophoblastic tissue. According to WHO, GTD was classified into three subgroups, such as- Neoplasm, non-neoplastic lesions and molar pregnancies. Clinical presentation, prognosis and management of each subgroups varies from one another. So, it is necessary to perfectly identify each subgroup among themselves and from their non-GTD mimickers, which is difficult to achieve based on histopathology alone. So, we employed Immuno-Histochemical (IHC) staining for CyclinE, that complements the histological diagnosis and hence in proper management of cases. MATERIALS AND METHODS This is a prospective study conducted in S.C.B. Medical College and Hospital in Odisha. Placentas of abortion cases, premature delivery as well as normal delivery were taken for study along clinical serological and radiological finding. The samples were subjected to histopathological examination and IHC analysis using Cycin-E as immunomarker. RESULTS This study includes 52 cases, out of which 38 were of GTD, 11 cases were of placenta of different gestational age those had no signs of molar changes or GTD, and 3 cases were of hydropic abortus. All trimester placenta showed a moderate score for cyclin-E, whereas maximum hydropic abortion sample not stained for cyclin-E (66.67%-score 0). 50% of CHM cases had score 3+ and maximum PHM cases had score 2+. Choriocarcinoma cases showed high score and also same for samples with exaggerated placental site. CONCLUSION IHC using cyclin-E as an immunomarker, has role as an adjunct to histopathological diagnosis in cases of GTD. Also, it helps in differentiating between the subgroups of GTD. However only one marker is not sufficient for definite diagnosis. So, more immunomarkers should be used in studies including a greater number of cases for a definite conclusion.
Authors and Affiliations
Rupa Das, Chandraprava Mishra, Narayan Chandra Mallik, Pallavi Bhuyan
Keywords
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- EP ID EP571149
- DOI 10.18410/jebmh/2018/523
- Views 89
- Downloads 0
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