Comparative Study of Effectiveness of Short Course versus Long Course Antimicrobial Prophylaxis after Clean Orthopedic Surgery - A Prospective Study of 200 Patients
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 7
Abstract
Introduction: Surgical site infection (SSI) is one of the most devastating complications associated with any surgical procedure. It is associated with prolonged morbidity, disability, and increased mortality. We assess the effectiveness of short-term (<48 h) versus long-term (14 days) antimicrobial prophylaxis therapy in preventing SSI after clean orthopedic surgeries. Materials and Methods: A random sample of 200 patients admitted for elective orthopedic surgeries performed under all aseptic precautions was divided into two equal groups with Group I given short-term (<48 h) and Group II given long-term (14 days) prophylaxis of the same antibiotic protocol. Both the groups underwent the predetermined protocol of investigations (complete blood count, erythrocyte sedimentation rate, C-reactive protein, BT/computed tomography, liver function tests, renal function test, urine routine, radiographs, and viral markers). They were evaluated on the basis of wound condition as per predetermined criteria on 2nd, 5th, 14th, and 28th days’ post-operative procedure. Results: The mean age of the patients in Groups I and II was 41.68 ± 16.95 years and 40.71 ± 17.22 years, respectively, and the female-to-male ratio in both the groups showed no significant statistical difference (P > 0.05). Mean duration of surgery in both the groups showed no significant difference. Two patients (2%) in Group I and three patients (3%) in Group II developed SSI which on statistical comparison showed no significant difference (P > 0.05). Conclusions: There is no benefit of prophylactic antibiotic after 48 h in clean elective orthopedic surgeries with short course antimicrobial prophylaxis being as effective as long course antimicrobial prophylaxis in developing country after clean elective orthopedic surgery.
Authors and Affiliations
Nishat Manherlal Goda, Dhaval Gordhanbhai Peshivadia
Keywords
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