Comparative study of efficacy and tolerability of Olmesartan with Ramipril in Type II diabetic and hypertensive Patients
Journal Title: Journal of Contemporary Medicine and Dentistry - Year 2016, Vol 4, Issue 1
Abstract
Background: Type 2 Diabetes Mellitus is commonly associated with hypertension. The reninangiotensin- aldosterone system (RAAS) plays a pivotal role in the pathogenesis of insulin resistance and cardiovascular disease in diabetes. Interruption of the RAAS with Angiotensin II type 1, (AT) receptor blockers (ARB) has been shown to prevent or reduce cardiovascular and renal disease progression in diabetic patients with hypertension. With this background we tried to evaluate the efficacy and tolerability of Olmesartan and Ramipiril. Methods: Study was conducted on 60 paents who were known diabecs and hypertensive aending the General Medicine clinic of Prathima Institute of medical Sciences Karimnagar. Results: The mean difference of 16 in SBP and mean difference of 7.69 in DBP in Ramipril group. Similarly mean difference of 19.8 in SBP and mean difference of 10 in DBP in Olmesartan group. The changes in both groups were statistically significant t-test shows the changes in Olmesartan group was found to be significant. There was mean difference of 4.19 in serum urea, mean difference of 0.05 in serum creanine and mean difference of 8.21 in albuminuria in Ramipril group. Similarly mean difference of 4.44 in serum urea, mean difference of 0.13 in serum creanine and mean difference of 24.8 in albuminuria in Olmesartan group. The changes in both groups were statistically significant t-test comparison of the changes in Olmesartan group was found to be significant. Conclusions: Olmesartan is a better choice in patients with type 2 Diabetes Mellitus with hypertension in comparison to Ramipril because of Better antihypertensive effect with achievement of target level blood pressure Better glycemic control (both short term and long term). Better improvement of serum creatinine and Urinary Albumin to Creatinine ratio and Good tolerability.
Authors and Affiliations
Jaya Babu Nagula, Mohd Rasheeduddin, Laxman Reddy Nadithe, Ravi Shankar Bhairi
Keywords
Related Articles
- EP ID EP449343
- DOI -
- Views 103
- Downloads 0
A Study on Prevalence and Associated Risk Factors for Type-2 Diabetes Mellitus in the Individuals Aged 20 Years and Above in Guntur City
complications. It is important to assess the various factors contributing to the occurrence of the diseases so that by limiting these factors the progression of the disease in patients can be controlled. Hence, the prese...
Prescription Pattern of Corticosteroids in Dermatology Cases in a Tertiary Care Teaching Hospital
Background: In recent times due to the inadvertent use of corticosteroids in dermatology and cosmetology clinics, drug utilization study is important in making necessary guidelines for using corticosteroids. Objective: T...
Effect of Exercise on Blood Pressure in Athletes and Untrained Individuals
Background: Physical exercise is known to increase heart rate and thus also causes proportionate changes in Blood Pressure. In the present study we tried to evaluate the changes occurring in Systolic Blood Pressure and D...
Gingival Pyogenic Granuloma – Case Report
Pyogenic Granuloma is an inflammatory hyperplastic soft tissue lesion of the skin and mucous membrane predominantly seen in young females primarily due to the hormonal changes during this period, expressed as a change in...
Role of Ulnar Length and Arm Span for Prediction of Pulmonary Function Test in Late Adolescent
Aims: The present study is aimed to evaluate the role of ulnar length & arm span for prediction of pulmonary function test in late adolescent. Material & Method: This study was conducted on 253 medical students (112 male...