COMPARATIVE STUDY OF EFFICACY BETWEEN RISPERIDONE AND HALOPERIDOL IN DRUG NAIVE ACUTE AND TRANSIENT PSYCHOTIC DISORDERS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 16
Abstract
BACKGROUND To compare the efficacy between risperidone and haloperidol in drug naïve acute and transient psychotic disorder patients attending Government Stanley Medical College Hospital by assessing the mean changes in PANSS total score from start to end of treatment. MATERIALS AND METHODS Patients (n=60) diagnosed as drug naïve acute and transient psychosis as per DSM-TR criteria & age between 18-60 years are recruited and randomly allocated into group A (n=30) Risperidone tab 4 mg daily & group B (n=30) Haloperidol tab 5 mg daily as decided by the treating psychiatric consultant, for the period of 3 months after obtaining informed consent by the patients family members. RESULTS The mean value for total PANSS score at the start of the study was 57.57 and reduced to 39.42 in Risperidone group; while in Haloperidol group the mean reduced from 81.00 to 57.06 with the p value of 0.012* (statistically significant at 5 level). CONCLUSION This study showed marked reduction in PANSS in drug naïve psychiatric patients with 60% of patients achieving primary outcome with Haloperidol and 73% of patients achieving primary outcome with Risperidone, however patients in Haloperidol group with initial high PANSS score showed marked reduction at the end of study.
Authors and Affiliations
Mohana Lakshmi M, Saravana Jothi R, Alexander Gnanadurai W. J, Jeevitha K, Jyosna B. N, Kalamathi B
Keywords
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- EP ID EP214510
- DOI 10.18410/jebmh/2017/179
- Views 102
- Downloads 0
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