Comparative Study of Epidural Dexmedetomidine and Magnesium Sulphate used as Adjuvant to Ropivacaine for Post-Operative Analgesia in Thoracotomy
Journal Title: International Journal of Anesthesiology & Research (IJAR) - Year 2016, Vol 4, Issue 5
Abstract
Background: Dexmedetomidine is the selective 2-adrenoceptor agonist with analgesic potency. Magnesium has antinociceptive effects in animal and human models of pain. Our hypothesis was that the addition of magnesium and dexmedetomidine to thoracic epidural bolus of ropivacaine may increases the duration of analgesia. Methods: Sixty patients undergoing thoracotomy were enrolled to receive either dexmedetomidine(Group D) or magnesium sulphate (Group M) till first epidural top up. In Group D, patients received 1 µg/kg dexmedetomidine +ropivacaine 0.375% and group M patients received magnesium sulphate 75 mg +ropivacaine 0.375% epidurally as an initial bolus dose. Pain assessment using a visual analogue scale (VAS), Time to reach maximum sensory block level, Sensory block level, first epidural top, heart rate, blood pressure sedation scores were observed in the postoperative period. In post – operative monitoring, any untoward complications like hypotension, hypertension, bradycardia, tachycardia, nausea, vomiting, respiratory depression were also observed. Results: The demographic profile of patients was comparable in both the groups. Time to reach maximum sensory block level in group D vs M (16.30±4.27 vs. 14.28 ±3.38) was significantly earlier in the M group. Postoperative analgesia was prolonged significantly in the D group (8.00±1.01 ) as compare to group M (5.27±0.69). Sedation scores were noted <3 in the group D. While the incidence of dry mouth, decrease heart rate significantly were higher in the D group. Incidence of nausea and vomiting, respiratory depression were similar in both group.
Authors and Affiliations
Anil Kumar Paswan
Keywords
Related Articles
- EP ID EP202305
- DOI 10.19070/2332-2780-1600054
- Views 114
- Downloads 0
Comparative Study of Epidural Dexmedetomidine and Magnesium Sulphate used as Adjuvant to Ropivacaine for Post-Operative Analgesia in Thoracotomy
Background: Dexmedetomidine is the selective 2-adrenoceptor agonist with analgesic potency. Magnesium has antinociceptive effects in animal and human models of pain. Our hypothesis was that the addition of magnesium and...
Comparison of Continuous Epidural Analgesia and Continuous Femoral Analgesia on Postoperative Pain and Knee Rehabilitation after Total Knee Arthroplasty
This study assessed the efficacy of postoperative analgesia and rehabilitation scores of continuous epidural analgesia or continuousfemoral analgesia after total knee arthroplasty. Thirty patients received epidural analg...
The effect of an Intravenous Ketamine Infusion on Postherpetic Neuralgia
Background: About 10~25% patients with herpes zoster suffers from postherpetic neuralgia (PHN). Yet, there is no certain treatment for PHN. Ketamine, an N-methyl-D-aspartate receptor (NMDA) antagonist, plays an important...
Our Experience of using Caudal Anesthesia in "Small" Surgical Interventions in Newborns
Aim of the Study: To study the effectiveness of anesthesia with caudal administration of ropivacaine in combination with intravenous administration of propofol in new borns with "small" surgeries. Material and Methods...
Paravertebral Block: A Comparative Study Evaluating Performance of Direct Surgical And Classic Technique
Introduction: Thoracic paravertebral block (TPVB) has been employed for post operative analgesia in thoracotomy. Paravertebral block can be given by various techniques, two most commonly used techniques include direct su...