Comparative Study of Epidural Dexmedetomidine and Magnesium Sulphate used as Adjuvant to Ropivacaine for Post-Operative Analgesia in Thoracotomy
Journal Title: International Journal of Anesthesiology & Research (IJAR) - Year 2016, Vol 4, Issue 5
Abstract
Background: Dexmedetomidine is the selective 2-adrenoceptor agonist with analgesic potency. Magnesium has antinociceptive effects in animal and human models of pain. Our hypothesis was that the addition of magnesium and dexmedetomidine to thoracic epidural bolus of ropivacaine may increases the duration of analgesia. Methods: Sixty patients undergoing thoracotomy were enrolled to receive either dexmedetomidine(Group D) or magnesium sulphate (Group M) till first epidural top up. In Group D, patients received 1 µg/kg dexmedetomidine +ropivacaine 0.375% and group M patients received magnesium sulphate 75 mg +ropivacaine 0.375% epidurally as an initial bolus dose. Pain assessment using a visual analogue scale (VAS), Time to reach maximum sensory block level, Sensory block level, first epidural top, heart rate, blood pressure sedation scores were observed in the postoperative period. In post – operative monitoring, any untoward complications like hypotension, hypertension, bradycardia, tachycardia, nausea, vomiting, respiratory depression were also observed. Results: The demographic profile of patients was comparable in both the groups. Time to reach maximum sensory block level in group D vs M (16.30±4.27 vs. 14.28 ±3.38) was significantly earlier in the M group. Postoperative analgesia was prolonged significantly in the D group (8.00±1.01 ) as compare to group M (5.27±0.69). Sedation scores were noted <3 in the group D. While the incidence of dry mouth, decrease heart rate significantly were higher in the D group. Incidence of nausea and vomiting, respiratory depression were similar in both group.
Authors and Affiliations
Anil Kumar Paswan
Keywords
Related Articles
- EP ID EP202305
- DOI 10.19070/2332-2780-1600054
- Views 133
- Downloads 0
Percutaneous Dilatational Tracheostomy: ULTRAperc® Single Stage Dilator Technique Versus Ciaglia Blue Dolphin® Balloon Dilatation Technique for Intubated Unweanable ICU Patients
Background: Percutaneous tracheostomy is currently one of the most common procedures performed in ICU. It has demonestrated provide numerous advantages over the classical surgical tracheostomy. The aim of this study is t...
Spinal Anesthesia for Transurethral Resection of Prostate: Levobupivacaine with or without Fentanyl
Background: The aim of the present study was to compare the characteristics of spinal blocks produced by low dose levobupivacaine (0.5%) and compare it when combined with fentanyl in transurethral resection of prostate....
Pediatric Renal Transplantation in Children with Weight 20kg or Less: A Single-Center Experience
Background: Renal transplantation (RT) is the treatment of choice for children with Chronic Kidney Disease (CKD). This technique benefits survival and quality of life. Long-term outcomes in pediatric transplantation have...
Prospective Study of Proportions and Causes of Cancellation of Surgical Operations at Jimma University Teaching Hospital, Ethiopia
Background: Cancellation of scheduled surgery is a major quality of health care problem affecting the individual patients, family and the actual health care organization. Objective: The aim of this study was to assess t...
Ultrasound-Guided Caudal Block for Anal Canal Surgery: A Prospective Cohort Study
Introduction: Postoperative pain is an important symptom in patients after non-oncological anal canal surgery. A caudal block has shown to be an effective analgesic technique in this type of surgery, and ultrasound facil...