COMPARATIVE STUDY OF HORMONE ANALYSIS IN PCOS INDUCED RAT AND TREATED WITH FISH OIL, SHELL FISH OIL AND METFORMIN
Journal Title: PARIPEX-Indian Journal of Research - Year 2019, Vol 8, Issue 5
Abstract
Polycystic ovary syndrome (PCOS) is a very common endocrine disorder among women in their reproductive age, characterized by polycystic ovary, hyperandrogenism, insulin resistance and menstrual irregularity. The present study was undertaken to determine the effect of sardine oil and krill oil in the treatment of letrozole induced PCOS in Wistar albino female rats on Follicle Stimulating Hormone, Luteinizing Hormone, Thyroid Stimulating Hormone. Estradiol, Progesterone and Testosterone. The rats were induced PCOS with letrozole for 21 days and treated with fish oil, shell fish oil and Metformin for 30 days and 60 days. The results showed that the hormone levels altered after the treatment. Hence, it may be concluded that the hormonal fluctuation caused in PCOS was brought to nearly normal levels by Omega-3 fatty acid present in the sardine oil and krill oil thus showing its potential effect and an alternative to metformin in treating PCOS.
Authors and Affiliations
Smita B. Pillai, Bhavita Chavan
Keywords
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