COMPARATIVE STUDY OF INTRATHECAL MIDAZOLAM VERSUS MAGNESIUM SULPHATE AS AN ADJUVANT TO HYPERBARIC BUPIVACAINE.
Journal Title: INTERNATIONAL JOURNAL OF ADVANCED MEDICINE - Year 2019, Vol 3, Issue 2
Abstract
Background: Intrathecal drugs when used as adjuvant to spinal anaesthesia produce substantial anti-nociception and potentiate analgesia of bupivacaine. This study was planned to evaluate the effects of intrathecal non opioid drug midazolam and magnesium sulphate on duration of analgesia, characteristics of SAB and hemodynamic stability when added to 0.5% hyperbaric bupivacaine for spinal anaesthesia. Methods: Sixty ASA physical status I-II patients of age group between 20 to 60 years with elective forearm and hand surgery under brachial plexus blocks were randomly allocated into two equal groups in a randomised double blind fashion. Group MZ received midazolam 2mg and Group MG received Mgso4 50mg with 15mg hyperbaric bupivacaine. The onset time and duration of sensory and motor blocks, quality of intraoperative analgesia and duration of analgesia were assessed. Results: The duration of postoperative analgesia was signicantly prolonged in MZ group 391.64 (132.98) minutes as compared to MG group 252.2 (86.76) minutes (P < 0.05). The numbers of analgesic doses in 24 hours were signicantly less in BM group.Time of onset of sensory and motor block was signicantly less in group MZ as compared to group MG (P < 0.05). The duration of the sensory and motor block as well as duration of post-operative analgesia was signicantly more in group BM as compared with group BMG (P<0.05), but there was no statistically signicant difference between both the groups with respect to the heart rate, mean arterial pressure and spo2. Conclusions: Intrathecal midazolam 2mg provides superior analgesia without clinically relevant side effects. The onset of analgesia was rapid and duration of sensory and motor block was prolonged with intrathecal midazolam and it also prolongs the duration of post-operative analgesia.
Authors and Affiliations
Dr. Ankit singh, Dr. Neelesh Nema
POST-THERAPY OUTCOME AND ECHOCARDIOGRAPHIC ANALYSIS AT THREE WEEKS OF ELDERLY PATIENTS WITH ACUTE MYOCARDIAL INFARCTION FOLLOWING THROMBOLYSIS THERAPY
Introduction: Once severe ischemia has lasted for about 20 minutes, myocardial necrosis ensues, affecting the subendocardium rst and then proceeding in a time dependent wave front to reach epicardium about 4 to 6 hours...
GLIOMATOSIS CEREBRI (GC), PRESENTATION, MANAGEMENT & PROGNOSTIC OVERVIEW.
Gliomatosis cerebri (GC) is a rare, inltrating glioma of brain & spinal cord. It is affects children, adult & elder age groups.Objective: To have an overview on the clinical presentation, management, prognosis & surviva...
STUDY ON ANAEMIA AMONG ADOLESCENT FEMALES BASED ON DIETARY HABITS
AIMS OBJECTIVES: To nd out the effects of Dietary habits on prevalence of anaemia in adolescent females of one of the urban area of Bhubaneswar. MATERIALS AND METHODS: 290 adolescent females were included in study. The...
CORRELATION BETWEEN NEONATAL SEPSIS WITH SERUM CRP AND PLATELET INDICES (PLATELETS COUNT, MPV & PDW
Background of study: Neonatal sepsis causes signicant mortality and long term morbidity in neonates, especially for preterm infants of very low birth weight. Objective: To ndout correlation between neonatal sepsis with...
SUBJECTIVE BENEFIT VERSUS SLEEP INERTIA AFTER SHORT POST LUNCH NAP
AIM: The aim of this randomized controlled study was to examine the subjective and objective effects of a brief postlunch nap in the workplace. PARTICIPANTS: 42-adult work at Royal Brisbane Hospital, Australia who had no...