COMPARATIVE STUDY OF METFORMIN AND VILDAGLIPTIN FOR MANAGEMENT OF PATIENTS WITH TYPE 2 DIABETES MELLITUS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 75
Abstract
BACKGROUND Diabetes mellitus is a major health problem which increases the rate of morbidity and mortality. Cheap Metformin and costlier vildagliptin are the frequently used oral hypoglycaemic agents. The comparative effectiveness of metformin and vildagliptin has not been studied earlier. So, this study was conducted to compare the antidiabetic efficacy of metformin and vildagliptin and their effects on renal function in patients with type 2 diabetes mellitus. MATERIALS AND METHODS It was a prospective, open-labelled, non-randomised, phase IV clinical trial which was carried out over the duration of 12 weeks. The patients attending the medicine outpatient department of Tripura Medical College (TMC) hospital were enrolled in the study. Patients, who fulfilled the selection criteria, were allocated in two treatment groups. Group A was treated with metformin (Sustained release preparation) 500 mg once daily and group B was treated with vildagliptin 50 mg once daily. Measurement of body weight, fasting blood glucose (FPG), postprandial blood glucose (PPG), glycated haemoglobin (HbA1c), serum urea, creatinine and urine albumin/creatinine ratio was performed at the initial visit and at the end of 12 weeks of treatment. RESULTS Metformin and vildagliptin significantly reduced the levels of FPG, PPG & HbA1c at week #12 from their respective baseline values. There was similar reduction in the level of HbA1c in both groups. Vildagliptin significantly reduced urine ACR at week #12 from baseline value. CONCLUSION The study shows that metformin and vildagliptin have similar effect on glycaemic control, but vildagliptin exerts better renoprotective effect and there were no reports of serious adverse events.
Authors and Affiliations
Lakshman Das, Mukut Roy, Ranjib Ghosh
Keywords
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- EP ID EP266976
- DOI 10.14260/Jemds/2017/1165
- Views 78
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