Comparative study of oral iron therapy and intravenous iron therapy in iron deficient pregnant women
Journal Title: Medpulse International Journal of Gynaecology - Year 2017, Vol 3, Issue 1
Abstract
Background: The importance of anemia as a major public health problem throughout the world is widely recognized. Anemia due to iron deficiency is the commonest malnutrition disorder seen throughout the world and in India. Apart from anemia, iron deficiency is also associated with preterm labour, pre-eclampsia, sepsis, hemorrhage, low birth weight delivery. The present study was planned to compare the effect of parenteral iron and daily oral iron supplementation on iron status of average pregnant Indian women by evaluating the blood indices. Aims and objectives: 1) To compare the response of intravenous iron sucrose with that of oral ferrous sulphate in the treatment of iron deficiecy anemia in pregnancy. 2) To compare the acceptability, efficacy and side effects of injectable intravenous iron over oral ferrous sulphate in the treatment of iron deficiency anemia in pregnancy. Material and Methods: A comparative study of oral iron (ferrous sulphate) therapy and intravenous iron (sucrose) therapy in iron deficient pregnant women is a prospective randomized controlled interventional study conducted at Department of Obstetrics and Gynaecology over a period of 2 years. Antenatal mothers coming in ANC OPD were included in this study. The mothers who were willing to participate and gave consent were included in the study. Results: 1) Primigravidas comprised the maximum number of patients in both the groups (46 and 38%). 2) The median dose administered was 600-700 mg i.e. 6-7 ampoules of 100 mg elemental iron intravenous group. 3) The percentage rise in hemoglobin art one and three weeks of tratment was statistically significant when compared to the baseline. 4) Statistically significant rise in hemoglobin, PCV and serum ferritin levels were found at one week and three weeks in intravenous group when compared to oral group. 5) None of the patients in the intravenous group had any of the dreaded side effects which are known to occur with intravenous preparations. Conclusion: The intravenous iron sucrose is safe and highly efficacious for the treatment of anemia in pregnancy.
Authors and Affiliations
Qurram Khan, P E Bhingare, S N Gadappa, Leela A Madane
Keywords
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