Comparative study of platelet indices in coronary artery diseases
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 4
Abstract
Introduction With urbanization and increase in sedentary lifestyle prevalence of CAD Coronary artery disease is looming large as the new epidemic afflicting Indians Altered platelet morphology and functions have been linked with the formation and propagation of thrombotic event Platelet indices Mean platelet volume MPV Platelet distribution width PDW Platelet large cell ratio PLCR are determinants of platelet functionalityAims and Objectives 1 To study platelet indices MPV PDW PLCR in CAD 2 To compare platelet indices in patients with myocardial infarction stable CAD and control populationMaterial and Methods A comparative and prospective study was conducted on 100 patients each of MI stable CAD on antiplatelet therapy and 100 age and sex matched healthy individuals as controls Platelet indices were measured using an Automated Blood Counter SYSMEX XN1000 Troponin T and CKMB levels were collected from clinical data in MI casesResults Platelet indices were significantly higher in MI patients in comparison to stable CAD and control groups Stable CAD patients also showed significantly higher platelet indices in comparison to control groups p value Conclusion The present study showed a significantly higher MPV PDW and PLCR in CAD patients in comparison to control group Among CAD patients MI patients had significantly higher platelet indices than stable CAD patients Hence platelet indices can be used as simple and cost effective predictive parameters to predict CAD Their use in a risk stratification system to predict MI and in response to intervention are worthy of considerationKeywords Coronary artery diseases Platelet indices Mean platelet volume Platelet distribution width Platelet large cell ratio
Authors and Affiliations
Gururajaprasad C, Ishita Maheshkumar Kaneria, Akkamahadevi P, Manjappa Mahadevappa
Keywords
Related Articles
- EP ID EP475922
- DOI 10.18231/2394-6792.2018.0112
- Views 45
- Downloads 0
Post-donation variations in various hematological parameters, serum ferritin and Hba1c level in diabetic and non-diabetic donors: A study report
Introduction Whole blood donation is almost obsolete in developed country but still itrsquos the main stay of transfusion practice in developing countries Iron deficiency is a complication of regular blood donationObject...
Evaluation and comparative analysis of minimal formalin containing compound fixatives
Introduction Fixation is the crucial step in the practice of diagnostic pathology Formalin has been used as a general fixative for more than a century The IARC International Agency for Research on Cancer reported that th...
Frequency and distribution of ABO and Rh Blood Group Antigens in Healthy Blood Donors at the Blood Bank of a Tertiary Care Hospital in Gandhinagar, Gujarat, India
Introduction: There are many blood group systems to classify red blood cells based on the presence of inherited antigens on their surface. Blood group antigens are inherited antigens and they already appear early in intr...
A study of Ki 67 immunostaining in breast carcinomas: Correlation with histopathological prognostic factors
Background: One of the most common causes of carcinoma deaths among women is breast cancer. In view of the above, early diagnosis and effective treatment of the disease are immensely important. The increasing number of o...
Lesions of uterine cervix by cytology and histopathology- A prospective study for a period of two years
Background: Carcinoma uterine cervix is one of the leading causes of cancer death among women worldwide. It is well known that cervical cancer morbidity and mortality could be significantly reduced with an active cervica...