Comparative Study of Serum PRL, LH, FSH in Overt and Subclinical Hypothyroid Females in Reproductive Age Group
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
Hypothyroidism is associated with an increase in the levels of thyroid releasing hormone (TRH) which in turn stimulates secretion of thyroid stimulating hormone (TSH) and prolactin (PRL). PRL inhibits the synthesis and secretion of gonadotropins (FSH & LH). Abnormal menstrual patterns are commonly observed in overt hypothyroidism.1 Studies considering an association between overt hypothyroidism and female reproductive hormones are not adequate particularly in eastern India. Therefore, present study is aimed to evaluate the relationship between overt and subclinical hypothyroidism and female reproductive hormones. Subjects were randomly selected having high TSH level.They were categorized into subclinical and overt hypothyroid. Results were analysed by using Graph pad prism 5, comparison was done using independent group t test and correlation was determined by Pearson’s correlation coefficient. Result showed that with overt hypothyroidism PRL increased and FSH & LH decreased significantly whereas in subclinical hypothyroidism PRL increased but FSH and LH are not significantly decreased. Most of the patients presented with oligomenorrhea .
Authors and Affiliations
Srila Ghosh Chowdhury, Amiya Kumar Sarkar
Keywords
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- EP ID EP441057
- DOI 10.9790/0853-1801126568.
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