Comparative Study of Succinylcholine with Different Doses of Rocuronium Bromide for Tracheal Intubation during General Anaesthesia
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
Background and objective: Tracheal intubation is one of the best methods of securing a patient airway. Though many non-depolarising muscle relaxants (NDMRs) like atracurium besylate, vecuronium bromide and mivacurium chloride were introduced, they however have not matched the timing and intubating conditions produced by succinylcholine. The new NDMR drug rocuronium bromide became the first competitor for succinylcholine as it produces excellent cardiovascular stabilityand is devoid of the adverse effects that are seen with succinylcholine. Hence, the present study was undertaken to compare the intubating conditions, hemodynamic changes and adverse effects of using injection succinylcholine 1 mg/kg with two doses of injection rocuronium bromide 0.6 mg/kg and 1 mg/kg body weight during general anaesthesia in adult patients. Methodology: The study population consisted of 90 patients aged between 18-60 years posted for various elective surgeries requiring general anaesthesia. Study population was randomly divided into 3 groups with 30 patients in each sub group. Group A received injection succinylcholine 1mg/kg body weight and intubation, group B received injection rocuronium bromide 0.6 mg/kg body weight and group C received injection rocuronium bromide 1mg/kg body weight and intubation attempted at 60 seconds. Intubating conditions were assessed at 60 seconds based on the scale adopted by Toni Magorian et al. 1993. Results: It was found that succinylcholine 1mg/kg body weight and rocuronium bromide 1mg/kg body weight produced excellent intubating condition in 96.7% and 93.3% of the patients, respectively whereas rocuronium bromide 0.6mg/kg produced excellent intubating condition in only 50% of the patients and the difference was statistically significant. Rocuronium bromide 0.6 mg/kg produced significant increase in heart rate, systolic blood pressure, diastolic blood pressure from baseline as compared to succinylcholine 1mg/kg and rocuronium bromide 1 mg/kg, post induction. Conclusion: Thus, from the present study, it is clear that Rocuronium is a safe, haemodynamically stable and good alternative for succinylcholine for endotracheal intubation at 60 seconds and can be used for safe intubation, if there is no anticipation of difficult intubation.
Authors and Affiliations
Rajesh Panda, Priyadarshani Padhihari, Jack Meitei, N. Ratan Singh, Kishore Kumar Behera, Subrat Kumar Nayak
Keywords
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