Comparative study of the outcome of pediatric subacute sclerosing pan-encephalitis patients treated with oral ribavirin versus intraventricular interferon alpha 2b via Ommaya reservoir
Journal Title: Pediatric Review: International Journal of Pediatric Research - Year 2018, Vol 5, Issue 6
Abstract
Introduction: Subacute sclerosing pan-encephalitis is a childhood disease occurring after a latent period of 2–12 years due to persistent defective measles virus within the neurons and glial cells. Various drugs have been used in treating SSPE with mixed success. Methods: All patients diagnosed with SSPE at the Neurology department from January 2011 to March 2018 were included in the study. Initially (upto January 2015) all patients of SSPE were treated with oral ribavirin (Group 1, N=8). Thereafter, when we received the Government supply of interferon alpha 2b, we shifted to its intraventricular administration via Ommaya reservoir (Group 2, N=9). The data was retrospectively collected from the medical records of the patients. Results: No statistically significant difference existed in the baseline parameters of the patients of the two groups. Patients of Group 2 had significantly better outcome in terms of reduction in Jabbour staging, cerebrospinal fluid measles antibody titre and Brief Assessment Examination scores. Lower age, lower latent period between measles infection and onset of clinical features of SSPE and higher Jabbour staging predicted the poor outcome in the univariate analysis. Conclusion: Intraventricular interferon alpha therapy is far superior to oral ribavirin. However, all studies with interferon alpha did not report significantly favorable outcome, thereby, necessitating further multicentric studies with larger sample sizes.
Authors and Affiliations
Kartick Chandra Ghosh, Ramesh Bhattacharya, Saikat Ghosh, Manoj Mahata, Sarbajit Das, Suman Das, Gourango Prosad Mondal
Clinical, Neurodevelopmental and Etiological profile of children with Cerebral Palsy
Background: Clinical spectrum of cerebral palsy (CP) is different in developing and developed countries. We evaluated the clinical profile, etiological factors and co-morbidities of children with CP in central India. Met...
Predictive value of umbilical cord blood bilirubin and albumin for significant hyperbilirubinemia in ABO incompatibility
Introduction: ABO incompatibility is the most common cause of hemolytic disease of the newborn with approximately 15% of live births at risk. The objective of this study wasto estimate the levels of bilirubin and albumin...
Growth and neurodevelopmental outcome of neonatal intensive care Unit graduates till 1 year at a tertiary care centre in eastern India and identification of the clinical and electrophysiological predictors of adverse developmental outcome
Background: Despite serious neonatal morbidity, the neurodevelopmental outcome of NICU (Neonatal Intensive Care Unit) graduates is often reasonably good. Infants with neurodevelopmental abnormality need to start therapy...
Clinical study of prevalence of obesity and over weight among school going adolescents in the age group of 11-17 years of Kangra district
Introduction: According to the World Health Organization (WHO), obesity can be defined as the accumulation of body fat in an abnormal and/or excessive manner showing serious health problems. The disruption of the normal...
Balloon dilatation of native coarctation of aorta in infants - short term clinical result
Background: Balloon dilatation with or without placement of stent in native coarctation offers a good alternative to surgery. Aim: To determine feasibility and safety of primary balloon angioplasty in infants with coarct...