Comparative study of transdermal NTG versus oral nifedipine with respect to neonatal outcome in patients with preterm labour
Journal Title: MedPulse -International Medical Journal - Year 2017, Vol 4, Issue 4
Abstract
Background: Preterm birth remains one of the main causes of perinatal mortality and long-term morbidity. More than 70% of the total perinatal mortality can be attributed to preterm birth. Aims and Objectives: To study of transdermal NTG versus oral Nifedipine in treatmnent of Pretern labour with respect to neonatal outcome. Methodology: This randomized study was conducted in the department of obstetrics and Gynaecology, SMGS Hospital, Jammu over a period of one year. Women with preterm labour between 26 weeks and 34 weeks gestation were studied. Preterm labour is defined as presence of regular and painful uterine contractions at the rate of 4 contractions in 20 minutes, with the evidence of cervical changes as effacement and/or dilatation. Total 50 patients were enrolled, 25 were in transdermal nitroglycerine group (study group) and 25 in oral nifedipine group (control group). After delivery, parameters of perinatal outcome were recorded including period of gestation, live born or still birth, weight of new born, apgar score at 1minute and 5 minutes, admission to neonatal intensive care unit (NICU) and history of respiratory distress syndrome. The statistical analysis done by un-paired t-test. Result: Apgar score of the neonates at birth with respect to response to the treatment. When studied it was seen that those who were born before 48 hours of initiation of therapy had a mean apgar score of 5.5 ± 3.01 and those who were born after 48 hours of initiation of therapy had mean apgar score of 8.5±1.15, and it was seen that the difference was statistically highly significant (p<0.0001). The mean brithweight of neonates in the study group was 2.39±0.59 kg and in the control group 2.59±0.73 kg. the difference of mean birth weight in two groups was not statistically significant. The mean length of stay in the neonatal intensive care unit of neonates in the study group was 1.6 days and in control group was 2.13 days. The difference was statistically not significant. The overall neonatal outcome in the two groups was not statistically significant. Conclusion: It was seen that those who were born before 48 hours of initiation of therapy had a mean apgar score less and those who were born after 48 hours of initiation of therapy had good apgar score. The overall neonatal outcome in the two groups was not statistically significant means both of the drugs are equally effective.
Authors and Affiliations
Anuradha *, Bhanu Mahajan, Shahana Jabeen, Parikh Rana, Rajni Razdan
Keywords
Related Articles
- EP ID EP176525
- DOI -
- Views 69
- Downloads 0
Efficacy of performing Septoplasty in allergic rhinitis
Introduction: Allergic rhinitis is an allergic reaction that happens when your immune system overreacts to substances that you inhale, such as pollen. The two types of allergic rhinitis are: Seasonal allergic rhinitis (h...
A comparative study of surgical outcome and recurrence of pterygium on surgical excision of pterygium (bare sclera method) and surgical excision with conjunctival autograft
In the present study, we aims to complete removal of pterygium itself and Placement of graft in place of the pterygium that will serve as a barrier to new growth. At times part of tenons is also needs to remove as it pro...
Chest ultrasound for respiratory distress in preterm newborn
Study was carried out to assess benefits of chest ultrasound in preterm neonates having respiratory distress. This was done for better and more reliable assessment of treatment and to reduce the radiation dose.
Management of extra-articular fractures of proximal shaft tibia in adults by antegrade closed interlock intramedullary nailing and evaluation of clinical results – A prospective study
Background: Extra-articular proximal tibial fractures accounts for 5 to 11% of all tibial shaft fractures. Intramedullary fixation of these fractures is associated with malalignment because of displacing muscular forces...
A Study of Immediate Outcome of Caesarian Section in Primiparous Patients
Abstract: Introduction: The reasons for increased incidence of cesarean section in primiparous patients are obvious. Firstly, increased safety of this operation has widened the indications both maternal and fetal. Second...