Comparative study of transdermal NTG versus oral nifedipine with respect to neonatal outcome in patients with preterm labour
Journal Title: MedPulse -International Medical Journal - Year 2017, Vol 4, Issue 4
Abstract
Background: Preterm birth remains one of the main causes of perinatal mortality and long-term morbidity. More than 70% of the total perinatal mortality can be attributed to preterm birth. Aims and Objectives: To study of transdermal NTG versus oral Nifedipine in treatmnent of Pretern labour with respect to neonatal outcome. Methodology: This randomized study was conducted in the department of obstetrics and Gynaecology, SMGS Hospital, Jammu over a period of one year. Women with preterm labour between 26 weeks and 34 weeks gestation were studied. Preterm labour is defined as presence of regular and painful uterine contractions at the rate of 4 contractions in 20 minutes, with the evidence of cervical changes as effacement and/or dilatation. Total 50 patients were enrolled, 25 were in transdermal nitroglycerine group (study group) and 25 in oral nifedipine group (control group). After delivery, parameters of perinatal outcome were recorded including period of gestation, live born or still birth, weight of new born, apgar score at 1minute and 5 minutes, admission to neonatal intensive care unit (NICU) and history of respiratory distress syndrome. The statistical analysis done by un-paired t-test. Result: Apgar score of the neonates at birth with respect to response to the treatment. When studied it was seen that those who were born before 48 hours of initiation of therapy had a mean apgar score of 5.5 ± 3.01 and those who were born after 48 hours of initiation of therapy had mean apgar score of 8.5±1.15, and it was seen that the difference was statistically highly significant (p<0.0001). The mean brithweight of neonates in the study group was 2.39±0.59 kg and in the control group 2.59±0.73 kg. the difference of mean birth weight in two groups was not statistically significant. The mean length of stay in the neonatal intensive care unit of neonates in the study group was 1.6 days and in control group was 2.13 days. The difference was statistically not significant. The overall neonatal outcome in the two groups was not statistically significant. Conclusion: It was seen that those who were born before 48 hours of initiation of therapy had a mean apgar score less and those who were born after 48 hours of initiation of therapy had good apgar score. The overall neonatal outcome in the two groups was not statistically significant means both of the drugs are equally effective.
Authors and Affiliations
Anuradha *, Bhanu Mahajan, Shahana Jabeen, Parikh Rana, Rajni Razdan
Keywords
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