Comparative Study of Two Different doses of Intrathecal Clonidine with Bupivacaine for Postoperative Analgesia
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2018, Vol 5, Issue 5
Abstract
Background: a2-agonist prolongs the duration of intrathecally administered local anaesthetics. This study was planned to investigate the effects of 45 µg and 90µg clonidine added to 0.5% intrathecal hyperbaric bupivacaine for postoperative analgesia. Materials and Methods: This prospective study was conducted in 90 patients of ASA grade I and II, both sex and aged between 20-60years. Patients were randomly allocated to Group A receiving normal saline+bupivacaine, Group B receiving a combination of 45µg clonidine+bupivacaine and Group C receiving combination of 90µg clonidine+bupivacaine. Sensory block, Motor block, sedation score and hemodynamic parameters were recorded. Results: Time for onset of sensory block (2.9±0.78 min) and motor block (6.27±0.98 min) was significantly lowest in group C (2.9±0.78 min). (p<0.01) The duration of analgesia was significantly higher in group C (495.33±34.2 min) (p<0.05). The motor block was most prolonged and intense in group C (2.0±0.0 score at 1.5 hr). Maximum sedation was seen at the end of 3 hrs with mean score of 2.1±0.37 in group C as compared to 2.1±0.3 in group B and 1.06±0.2 in Group A. There was no significance difference between the groups for fall of blood pressure. Hypotension and bradycardia were significantly higher in group B and group C as compared to group A, but was within acceptable limits. Conclusion: Intrathecal 90 µg clonidine seems to be the optimum safe dose because it significantly prolongs postoperative analgesia and markedly decreases supplementary analgesic demand with minimum hemodynamic changes.
Authors and Affiliations
Jayshri P. Prajapati
Keywords
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- EP ID EP537875
- DOI 10.21088/ijaa.2349.8471.5518.8
- Views 100
- Downloads 0
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