Comparative Study of Varying Doses of Dexmedetomidine Combined with Levobupivacaine in Supraclavicular Brachial Plexus Block: A Randomized Double-Blind Prospective Study
Journal Title: International Journal of Research and Review - Year 2018, Vol 5, Issue 11
Abstract
Background: Regional anesthesia is a recommended technique for upper and lower limb surgeries with better postoperative profile. The ideal dose of dexmedetomidine for brachial plexus block is a matter of debate. Few studies compared the effect of different doses of dexmedetomidine. Aims and Objectives: This study was carried out to evaluate 50 μg or 100 μg of dexmedetomidine added to 0.5% levobupivacaine, with regard to the duration of analgesia. Materials and Methods: 120 patients undergoing upper limb surgeries under supraclavicular brachial plexus block were randomly allocated into two groups. Group LD50 (n=60) received 29 ml of 0.5% levobupivacaine plus 50 μg of dexmedetomidine diluted in 1 ml of normal saline. Group LD100 (n=60) received 29 ml of 0.5% levobupivacaine plus 100 μg of dexmedetomidine diluted in 1 ml of normal saline. Duration of analgesia was the primary outcome observed. Results: The duration of analgesia was significantly prolonged in group LD100 when compared to LD50 group (P = 0.001). Significantly fewer patients in group LD100 required rescue analgesia. Conclusion: Dexmedetomidine 100 μg used for brachial plexus block showed quicker onset and prolonged duration of sensorimotor blockade and analgesia, but had higher incidence of bradycardia and sedation.
Authors and Affiliations
Dr. Inugala Rajkumar Reddy
Keywords
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